WD repeat-containing protein 54
1_MFRWE 6_ RSIPL 11_ RGSAA 16_ ALCNN 21_ LSVLQ 26_ LPARN 31_ LTYFG 36_ VVHGP 41_ SAQLL 46_ SAAPE 51_ GVPLA 56_ QRQLH 61_ AKEGA 66_ GVSPP 71_ LITQV 76_ HWCVL 81_ PFRVL 86_ LVLTS 91_ HRGIQ 96_ MYESN 101_ GYTMV 106_ YWHAL 111_ DSGDA 116_ SPVQA 121_ VFARG 126_ IAASG 131_ HFICV 136_ GTWSG 141_ RVLVF 146_ DIPAK 151_ GPNIV 156_ LSEEL 161_ AGHQM 166_ PITDI 171_ ATEPA 176_ QGQDC 181_ VADMV 186_ TADDS 191_ GLLCV 196_ WRSGP 201_ EFTLL 206_ TRIPG 211_ FGVPC 216_ PSVQL 221_ WQGII 226_ AAGYG 231_ NGQVH 236_ LYEAT 241_ TGNLH 246_ VQINA 251_ HARAI 256_ CALDL 261_ ASEVG 266_ KLLSA 271_ GEDTF 276_ VHIWK 281_ LSRNP 286_ ESGYI 291_ EVEHC 296_ HGECV 301_ ADTQL 306_ CGARF 311_ CDSSG 316_ NSFAV 321_ TGYDL 326_AEIRR
1: Plays a role in the adhesion and fusion of the sperm-oocyte membrane through its interactions with IZUMO1 and IZUMO1R/JUNO (By similarity). When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation (PubMed:30458214)