Actin-related protein 8 (hArp8) (INO80 complex subunit N)
1_MTQAE 6_ KGDTE 11_ NGKEK 16_ GGEKE 21_ KEQRG 26_ VKRPI 31_ VPALV 36_ PESLQ 41_ EQIQS 46_ NFIIV 51_ IHPGS 56_ TTLRI 61_ GRATD 66_ TLPAS 71_ IPHVI 76_ ARRHK 81_ QQGQP 86_ LYKDS 91_ WLLRE 96_ GLNKP 101_ ESNEQ 106_ RQNGL 111_ KMVDQ 116_ AIWSK 121_ KMSNG 126_ TRRIP 131_ VSPEQ 136_ ARSYN 141_ KQMRP 146_ AILDH 151_ CSGNK 156_ WTNTS 161_ HHPEY 166_ LVGEE 171_ ALYVN 176_ PLDCY 181_ NIHWP 186_ IRRGQ 191_ LNIHP 196_ GPGGS 201_ LTAVL 206_ ADIEV 211_ IWSHA 216_ IQKYL 221_ EIPLK 226_ DLKYY 231_ RCILL 236_ IPDIY 241_ NKQHV 246_ KELVN 251_ MILMK 256_ MGFSG 261_ IVVHQ 266_ ESVCA 271_ TYGSG 276_ LSSTC 281_ IVDVG 286_ DQKTS 291_ VCCVE 296_ DGVSH 301_ RNTRL 306_ CLAYG 311_ GSDVS 316_ RCFYW 321_ LMQRA 326_ GFPYR 331_ ECQLT 336_ NKMDC 341_ LLLQH 346_ LKETF 351_ CHLDQ 356_ DISGL 361_ QDHEF 366_ QIRHP 371_ DSPAL 376_ LYQFR 381_ LGDEK 386_ LQAPM 391_ ALFYP 396_ ATFGI 401_ VGQKM 406_ TTLQH 411_ RSQGD 416_ PEDPH 421_ DEHYL 426_ LATQS 431_ KQEQS 436_ AKATA 441_ DRKSA 446_ SKPIG 451_ FEGDL 456_ RGQSS 461_ DLPER 466_ LHSQE 471_ VDLGS 476_ AQGDG 481_ LMAGN 486_ DSEEA 491_ LTALM 496_ SRKTA 501_ ISLFE 506_ GKALG 511_ LDKAI 516_ LHSID 521_ CCSSD 526_ DTKKK 531_ MYSSI 536_ LVVGG 541_ GLMFH 546_ KAQEF 551_ LQHRI 556_ LNKMP 561_ PSFRR 566_ IIENV 571_ DVITR 576_ PKDMD 581_ PRLIA 586_ WKGGA 591_ VLACL 596_ DTTQE 601_ LWIYQ 606_ REWQR 611_ FGVRM 616_LRERA
1: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize
2: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex