E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7)
1_MESKP 6_ SRIPR 11_ RISVQ 16_ PSSSL 21_ SARMM 26_ SGSRG 31_ SSLND 36_ TYHSR 41_ DSSFR 46_ LDSEY 51_ QSTSA 56_ SASAS 61_ PFQSA 66_ WYSES 71_ EITQG 76_ ARSRS 81_ QNQQR 86_ DHDSK 91_ RPKLS 96_ CTNCT 101_ TSAGR 106_ NVGNG 111_ LNTLS 116_ DSSWR 121_ HSQVP 126_ RSSSM 131_ VLGSF 136_ GTDLM 141_ RERRD 146_ LERRT 151_ DSSIS 156_ NLMDY 161_ SHRSG 166_ DFTTS 171_ SYVQD 176_ RVPSY 181_ SQGAR 186_ PKENS 191_ MSTLQ 196_ LNTSS 201_ TNHQL 206_ PSEHQ 211_ TILSS 216_ RDSRN 221_ SLRSN 226_ FSSRE 231_ SESSR 236_ SNTQP 241_ GFSYS 246_ SSRDE 251_ APIIS 256_ NSERV 261_ VSSQR 266_ PFQES 271_ SDNEG 276_ RRTTR 281_ RLLSR 286_ IASSM 291_ SSTFF 296_ SRRSS 301_ QDSLN 306_ TRSLN 311_ SENSY 316_ VSPRI 321_ LTASQ 326_ SRSNV 331_ PSASE 336_ VPDNR 341_ ASEAS 346_ QGFRF 351_ LRRRW 356_ GLSSL 361_ SHNHS 366_ SESDS 371_ ENFNQ 376_ ESEGR 381_ NTGPW 386_ LSSSL 391_ RNRCT 396_ PLFSR 401_ RRREG 406_ RDESS 411_ RIPTS 416_ DTSSR 421_ SHIFR 426_ RESNE 431_ VVHLE 436_ AQNDP 441_ LGAAA 446_ NRPQA 451_ SAASS 456_ SATTG 461_ GSTSD 466_ SAQGG 471_ RNTGI 476_ SGILP 481_ GSLFR 486_ FAVPP 491_ ALGSN 496_ LTDNV 501_ MITVD 506_ IIPSG 511_ WNSAD 516_ GKSDK 521_ TKSAP 526_ SRDPE 531_ RLQKI 536_ KESLL 541_ LEDSE 546_ EEEGD 551_ LCRIC 556_ QMAAA 561_ SSSNL 566_ LIEPC 571_ KCTGS 576_ LQYVH 581_ QDCMK 586_ KWLQA 591_ KINSG 596_ SSLEA 601_ VTTCE 606_ LCKEK 611_ LELNL 616_ EDFDI 621_ HELHR 626_ AHANE 631_ QAEYE 636_ FISSG 641_ LYLVV 646_ LLHLC 651_ EQSFS 656_ DMMGN 661_ TNEPS 666_ TRVRF 671_ INLAR 676_ TLQAH 681_ MEDLE 686_ TSEDD 691_ SEEDG 696_DHNRT
1: E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7 (PubMed:37632749). Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation (PubMed:25594175)