Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D)
1_MAAAD 6_ AEAVP 11_ ARGEP 16_ QQDCC 21_ VKTEL 26_ LGEET 31_ PMAAD 36_ EGSAE 41_ KQAGE 46_ AHMAA 51_ DGETN 56_ GSCEN 61_ SDASS 66_ HANAA 71_ KHTQD 76_ SARVN 81_ PQDGT 86_ NTLTR 91_ IAENG 96_ VSERD 101_ SEAAK 106_ QNHVT 111_ ADDFV 116_ QTSVI 121_ GSNGY 126_ ILNKP 131_ ALQAQ 136_ PLRTT 141_ STLAS 146_ SLPGH 151_ AAKTL 156_ PGGAG 161_ KGRTP 166_ SAFPQ 171_ TPAAP 176_ PATLG 181_ EGSAD 186_ TEDRK 191_ LPAPG 196_ ADVKV 201_ HRARK 206_ TMPKS 211_ VVGLH 216_ AASKD 221_ PREVR 226_ EARDH 231_ KEPKE 236_ EINKN 241_ ISDFG 246_ RQQLL 251_ PPFPS 256_ LHQSL 261_ PQNQC 266_ YMATT 271_ KSQTA 276_ CLPFV 281_ LAAAV 286_ SRKKK 291_ RRMGT 296_ YSLVP 301_ KKKTK 306_ VLKQR 311_ TVIEM 316_ FKSIT 321_ HSTVG 326_ SKGEK 331_ DLGAS 336_ SLHVN 341_ GESLE 346_ MDSDE 351_ DDSEE 356_ LEEDD 361_ GHGAE 366_ QAAAF 371_ PTEDS 376_ RTSKE 381_ SMSEA 386_ DRAQK 391_ MDGES 396_ EEEQE 401_ SVDTG 406_ EEEEG 411_ GDESD 416_ LSSES 421_ SIKKK 426_ FLKRK 431_ GKTDS 436_ PWIKP 441_ ARKRR 446_ RRSRK 451_ KPSGA 456_ LGSES 461_ YKSSA 466_ GSAEQ 471_ TAPGD 476_ STGYM 481_ EVSLD 486_ SLDLR 491_ VKGIL 496_ SSQAE 501_ GLANG 506_ PDVLE 511_ TDGLQ 516_ EVPLC 521_ SCRME 526_ TPKSR 531_ EITTL 536_ ANNQC 541_ MATES 546_ VDHEL 551_ GRCTN 556_ SVVKY 561_ ELMRP 566_ SNKAP 571_ LLVLC 576_ EDHRG 581_ RMVKH 586_ QCCPG 591_ CGYFC 596_ TAGNF 601_ MECQP 606_ ESSIS 611_ HRFHK 616_ DCASR 621_ VNNAS 626_ YCPHC 631_ GEESS 636_ KAKEV 641_ TIAKA 646_ DTTST 651_ VTPVP 656_ GQEKG 661_ SALEG 666_ RADTT 671_ TGSAA 676_ GPPLS 681_ EDDKL 686_ QGAAS 691_ HVPEG 696_ FDPTG 701_ PAGLG 706_ RPTPG 711_ LSQGP 716_ GKETL 721_ ESALI 726_ ALDSE 731_ KPKKL 736_ RFHPK 741_ QLYFS 746_ ARQGE 751_ LQKVL 756_ LMLVD 761_ GIDPN 766_ FKMEH 771_ QNKRS 776_ PLHAA 781_ AEAGH 786_ VDICH 791_ MLVQA 796_ GANID 801_ TCSED 806_ QRTPL 811_ MEAAE 816_ NNHLE 821_ AVKYL 826_ IKAGA 831_ LVDPK 836_ DAEGS 841_ TCLHL 846_ AAKKG 851_ HYEVV 856_ QYLLS 861_ NGQMD 866_ VNCQD 871_ DGGWT 876_ PMIWA 881_ TEYKH 886_ VDLVK 891_ LLLSK 896_ GSDIN 901_ IRDNE 906_ ENICL 911_ HWAAF 916_ SGCVD 921_ IAEIL 926_ LAAKC 931_ DLHAV 936_ NIHGD 941_ SPLHI 946_ AAREN 951_ RYDCV 956_ VLFLS 961_ RDSDV 966_ TLKNK 971_ EGETP 976_ LQCAS 981_ LNSQV 986_ WSALQ 991_ MSKAL 996_ QDSAP 1001_ DRPSP 1006_ VERIV 1011_ SRDIA 1016_ RGYER 1021_ IPIPC 1026_ VNAVD 1031_ SEPCP 1036_ SNYKY 1041_ VSQNC 1046_ VTSPM 1051_ NIDRN 1056_ ITHLQ 1061_ YCVCI 1066_ DDCSS 1071_ SNCMC 1076_ GQLSM 1081_ RCWYD 1086_ KDGRL 1091_ LPEFN 1096_ MAEPP 1101_ LIFEC 1106_ NHACS 1111_ CWRNC 1116_ RNRVV 1121_ QNGLR 1126_ ARLQL 1131_ YRTRD 1136_ MGWGV 1141_ RSLQD 1146_ IPPGT 1151_ FVCEY 1156_ VGELI 1161_ SDSEA 1166_ DVREE 1171_ DSYLF 1176_ DLDNK 1181_ DGEVY 1186_ CIDAR 1191_ FYGNV 1196_ SRFIN 1201_ HHCEP 1206_ NLVPV 1211_ RVFMA 1216_ HQDLR 1221_ FPRIA 1226_ FFSTR 1231_ LIEAG 1236_ EQLGF 1241_ DYGER 1246_ FWDIK 1251_ GKLFS 1256_ CRCGS 1261_ PKCRH 1266_ SSAAL 1271_ AQRQA 1276_ SAAQE 1281_ AQEDG 1286_ LPDTS 1291_SAAAA
1: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity)