Gene name: SFXN1

Uniprot entry:

Q9H9B4

Protein names:

Sideroflexin-1

Protein sequence:

1_MSGEL 6_ PPNIN 11_ IKEPR 16_ WDQST 21_ FIGRA 26_ NHFFT 31_ VTDPR 36_ NILLT 41_ NEQLE 46_ SARKI 51_ VHDYR 56_ QGIVP 61_ PGLTE 66_ NELWR 71_ AKYIY 76_ DSAFH 81_ PDTGE 86_ KMILI 91_ GRMSA 96_ QVPMN 101_ MTITG 106_ CMMTF 111_ YRTTP 116_ AVLFW 121_ QWINQ 126_ SFNAV 131_ VNYTN 136_ RSGDA 141_ PLTVN 146_ ELGTA 151_ YVSAT 156_ TGAVA 161_ TALGL 166_ NALTK 171_ HVSPL 176_ IGRFV 181_ PFAAV 186_ AAANC 191_ INIPL 196_ MRQRE 201_ LKVGI 206_ PVTDE 211_ NGNRL 216_ GESAN 221_ AAKQA 226_ ITQVV 231_ VSRIL 236_ MAAPG 241_ MAIPP 246_ FIMNT 251_ LEKKA 256_ FLKRF 261_ PWMSA 266_ PIQVG 271_ LVGFC 276_ LVFAT 281_ PLCCA 286_ LFPQK 291_ SSMSV 296_ TSLEA 301_ ELQAK 306_ IQESH 311_ PELRR 316_VYFNK

Protein annotations

Protein functions:

1: Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778). May also transport other amino acids including alanine and cysteine (PubMed:30442778)