Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction)
1_MNRTK 6_ GDEEE 11_ YWNSS 16_ KFKAF 21_ TFDDE 26_ DDELS 31_ QLKES 36_ KRAVN 41_ SLRDF 46_ VDDDD 51_ DDDLE 56_ RVSWS 61_ GEPVG 66_ SISWS 71_ IRETA 76_ GNSGS 81_ THEGR 86_ EQLKS 91_ RNSFS 96_ SYAQL 101_ PKPTS 106_ TYSLS 111_ SFFRG 116_ RTRPG 121_ SFQSL 126_ SDALS 131_ DTPAK 136_ SYAPE 141_ LGRPK 146_ GEYRD 151_ YSNDW 156_ SPSDT 161_ VRRLR 166_ KGKVC 171_ SLERF 176_ RSLQD 181_ KLQLL 186_ EEAVS 191_ MHDGN 196_ VITAV 201_ LIFLK 206_ RTLSK 211_ EILFR 216_ ELEVR 221_ QVALR 226_ HLIHF 231_ LKEIG 236_ DQKLL 241_ LDLFR 246_ FLDRT 251_ EELAL 256_ SHYRE 261_ HLNIQ 266_ DPDKR 271_ KEFLK 276_ TCVGL 281_ PFSAE 286_ DSAHI 291_ QDHYT 296_ LLERQ 301_ IIIEA 306_ NDRHL 311_ ESAGQ 316_ TEIFR 321_ KHPRK 326_ ASILN 331_ MPLVT 336_ TLFYS 341_ CFYHY 346_ TEAEG 351_ TFSSP 356_ VNLKK 361_ TFKIP 366_ DKQYV 371_ LTALA 376_ ARAKL 381_ RAWND 386_ VDALF 391_ TTKNW 396_ LGYTK 401_ KRAPI 406_ GFHRV 411_ VEILH 416_ KNNAP 421_ VQILQ 426_ EYVNL 431_ VEDVD 436_ TKLNL 441_ ATKFK 446_ CHDVV 451_ IDTYR 456_ DLKDR 461_ QQLLA 466_ YRSKV 471_ DKGSA 476_ EEEKI 481_ DALLS 486_SSQIR
1: Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B (PubMed:19109425). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity)