Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3)
1_MEIGS 6_ AGPAG 11_ AQPLL 16_ MVPRR 21_ PGYGT 26_ MGKPI 31_ KLLAN 36_ CFQVE 41_ IPKID 46_ VYLYE 51_ VDIKP 56_ DKCPR 61_ RVNRE 66_ VVDSM 71_ VQHFK 76_ VTIFG 81_ DRRPV 86_ YDGKR 91_ SLYTA 96_ NPLPV 101_ ATTGV 106_ DLDVT 111_ LPGEG 116_ GKDRP 121_ FKVSI 126_ KFVSR 131_ VSWHL 136_ LHEVL 141_ TGRTL 146_ PEPLE 151_ LDKPI 156_ STNPV 161_ HAVDV 166_ VLRHL 171_ PSMKY 176_ TPVGR 181_ SFFSA 186_ PEGYD 191_ HPLGG 196_ GREVW 201_ FGFHQ 206_ SVRPA 211_ MWKMM 216_ LNIDV 221_ SATAF 226_ YKAQP 231_ VIQFM 236_ CEVLD 241_ IHNID 246_ EQPRP 251_ LTDSH 256_ RVKFT 261_ KEIKG 266_ LKVEV 271_ THCGT 276_ MRRKY 281_ RVCNV 286_ TRRPA 291_ SHQTF 296_ PLQLE 301_ NGQTV 306_ ERTVA 311_ QYFRE 316_ KYTLQ 321_ LKYPH 326_ LPCLQ 331_ VGQEQ 336_ KHTYL 341_ PLEVC 346_ NIVAG 351_ QRCIK 356_ KLTDN 361_ QTSTM 366_ IKATA 371_ RSAPD 376_ RQEEI 381_ SRLVR 386_ SANYE 391_ TDPFV 396_ QEFQF 401_ KVRDE 406_ MAHVT 411_ GRVLP 416_ APMLQ 421_ YGGRN 426_ RTVAT 431_ PSHGV 436_ WDMRG 441_ KQFHT 446_ GVEIK 451_ MWAIA 456_ CFATQ 461_ RQCRE 466_ EILKG 471_ FTDQL 476_ RKISK 481_ DAGMP 486_ IQGQP 491_ CFCKY 496_ AQGAD 501_ SVEPM 506_ FRHLK 511_ NTYSG 516_ LQLII 521_ VILPG 526_ KTPVY 531_ AEVKR 536_ VGDTL 541_ LGMAT 546_ QCVQV 551_ KNVIK 556_ TSPQT 561_ LSNLC 566_ LKINV 571_ KLGGI 576_ NNILV 581_ PHQRP 586_ SVFQQ 591_ PVIFL 596_ GADVT 601_ HPPAG 606_ DGKKP 611_ SIAAV 616_ VGSMD 621_ AHPSR 626_ YCATV 631_ RVQRP 636_ RQEII 641_ QDLAS 646_ MVREL 651_ LIQFY 656_ KSTRF 661_ KPTRI 666_ IFYRD 671_ GVSEG 676_ QFRQV 681_ LYYEL 686_ LAIRE 691_ ACISL 696_ EKDYQ 701_ PGITY 706_ IVVQK 711_ RHHTR 716_ LFCAD 721_ RTERV 726_ GRSGN 731_ IPAGT 736_ TVDTD 741_ ITHPY 746_ EFDFY 751_ LCSHA 756_ GIQGT 761_ SRPSH 766_ YHVLW 771_ DDNCF 776_ TADEL 781_ QLLTY 786_ QLCHT 791_ YVRCT 796_ RSVSI 801_ PAPAY 806_ YAHLV 811_ AFRAR 816_ YHLVD 821_ KEHDS 826_ AEGSH 831_ VSGQS 836_ NGRDP 841_ QALAK 846_ AVQIH 851_QDTLR
1: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity (PubMed:29040713)