KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog)
1_MNRIR 6_ IHVLP 11_ TNRGR 16_ ITPVP 21_ RSQEP 26_ LSCAF 31_ THRPC 36_ SHPRL 41_ EGQEF 46_ CIKHI 51_ LEDKN 56_ APFKQ 61_ CSYIS 66_ TKNGK 71_ RCPNA 76_ APKPE 81_ KKDGV 86_ SFCAE 91_ HVRRN 96_ ALALH 101_ AQMKK 106_ TNPGP 111_ VGETL 116_ LCQLS 121_ SYAKT 126_ ELGSQ 131_ TPESS 136_ RSEAS 141_ RILDE 146_ DSWSD 151_ GEQEP 156_ ITVDQ 161_ TWRGD 166_ PDSEA 171_ DSIDS 176_ DQEDP 181_ LKHAG 186_ VYTAE 191_ EVALI 196_ MREKL 201_ IRLQS 206_ LYIDQ 211_ FKRLQ 216_ HLLKE 221_ KKRRY 226_ LHNRK 231_ VEHEA 236_ LGSSL 241_ LTGPE 246_ GLLAK 251_ ERENL 256_ KRLKC 261_ LRRYR 266_ QRYGV 271_ EALLH 276_ RQLKE 281_ RRMLA 286_ TDGAA 291_ QQAHT 296_ TRSSQ 301_ RCLAF 306_ VDDVR 311_ CSNQS 316_ LPMTR 321_ HCLTH 326_ ICQDT 331_ NQVLF 336_ KCCQG 341_ SEEVP 346_ CNKPV 351_ PVSLS 356_ EDPCC 361_ PLHFQ 366_ LPPQM 371_ YKPEQ 376_ VLSVP 381_ DDLEA 386_ GPMDL 391_ YLSAA 396_ ELQPT 401_ ESLPL 406_ EFSDD 411_ LDVVG 416_ DGMQC 421_ PPSPL 426_ LFDPS 431_ LTLED 436_ HLVKE 441_ IAEDP 446_ VDILG 451_ QMQMA 456_ GDGCR 461_ SQGSR 466_ NSEKA 471_ SAPLS 476_ QSGLA 481_ TANGK 486_PEPTS
1: Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:33657400). Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac) (By similarity). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells (By similarity). Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA (By similarity)