COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) (JAB1-containing signalosome subunit 7b)
1_MAGEQ 6_ KPSSN 11_ LLEQF 16_ ILLAK 21_ GTSGS 26_ ALTAL 31_ ISQVL 36_ EAPGV 41_ YVFGE 46_ LLELA 51_ NVQEL 56_ AEGAN 61_ AAYLQ 66_ LLNLF 71_ AYGTY 76_ PDYIA 81_ NKESL 86_ PELST 91_ AQQNK 96_ LKHLT 101_ IVSLA 106_ SRMKC 111_ IPYSV 116_ LLKDL 121_ EMRNL 126_ RELED 131_ LIIEA 136_ VYTDI 141_ IQGKL 146_ DQRNQ 151_ LLEVD 156_ FCIGR 161_ DIRKK 166_ DINNI 171_ VKTLH 176_ EWCDG 181_ CEAVL 186_ LGIEQ 191_ QVLRA 196_ NQYKE 201_ NHNRT 206_ QQQVE 211_ AEVTN 216_ IKKTL 221_ KATAS 226_ SSAQE 231_ MEQQL 236_ AEREC 241_ PPHAE 246_ QRQPT 251_ KKMSK 256_VKGLV
1: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively