Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog)
1_MSVDP 6_ ACPQS 11_ LPCFE 16_ ASDCK 21_ ESSPM 26_ PVICG 31_ PEENY 36_ PSLQM 41_ SSAEM 46_ PHTET 51_ VSPLP 56_ SSMDL 61_ LIQDS 66_ PDSST 71_ SPKGK 76_ QPTSA 81_ EKSVA 86_ KKEDK 91_ VPVKK 96_ QKTRT 101_ VFSST 106_ QLCVL 111_ NDRFQ 116_ RQKYL 121_ SLQQM 126_ QELSN 131_ ILNLS 136_ YKQVK 141_ TWFQN 146_ QRMKS 151_ KRWQK 156_ NNWPK 161_ NSNGV 166_ TQKAS 171_ APTYP 176_ SLYSS 181_ YHQGC 186_ LVNPT 191_ GNLPM 196_ WSNQT 201_ WNNST 206_ WSNQT 211_ QNIQS 216_ WSNHS 221_ WNTQT 226_ WCTQS 231_ WNNQA 236_ WNSPF 241_ YNCGE 246_ ESLQS 251_ CMQFQ 256_ PNSPA 261_ SDLEA 266_ ALEAA 271_ GEGLN 276_ VIQQT 281_ TRYFS 286_ TPQTM 291_ DLFLN 296_YSMNM
1: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (PubMed:25825768). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation