Ribitol 5-phosphate transferase FKRP (EC 2.7.8.-) (Fukutin-related protein) (Ribitol-5-phosphate transferase)
1_MRLTR 6_ CQAAL 11_ AAAIT 16_ LNLLV 21_ LFYVS 26_ WLQHQ 31_ PRNSR 36_ ARGPR 41_ RASAA 46_ GPRVT 51_ VLVRE 56_ FEAFD 61_ NAVPE 66_ LVDSF 71_ LQQDP 76_ AQPVV 81_ VAADT 86_ LPYPP 91_ LALPR 96_ IPNVR 101_ LALLQ 106_ PALDR 111_ PAAAS 116_ RPETY 121_ VATEF 126_ VALVP 131_ DGARA 136_ EAPGL 141_ LERMV 146_ EALRA 151_ GSARL 156_ VAAPV 161_ ATANP 166_ ARCLA 171_ LNVSL 176_ REWTA 181_ RYGAA 186_ PAAPR 191_ CDALD 196_ GDAVV 201_ LLRAR 206_ DLFNL 211_ SAPLA 216_ RPVGT 221_ SLFLQ 226_ TALRG 231_ WAVQL 236_ LDLTF 241_ AAARQ 246_ PPLAT 251_ AHARW 256_ KAERE 261_ GRARR 266_ AALLR 271_ ALGIR 276_ LVSWE 281_ GGRLE 286_ WFGCN 291_ KETTR 296_ CFGTV 301_ VGDTP 306_ AYLYE 311_ ERWTP 316_ PCCLR 321_ ALRET 326_ ARYVV 331_ GVLEA 336_ AGVRY 341_ WLEGG 346_ SLLGA 351_ ARHGD 356_ IIPWD 361_ YDVDL 366_ GIYLE 371_ DVGNC 376_ EQLRG 381_ AEAGS 386_ VVDER 391_ GFVWE 396_ KAVEG 401_ DFFRV 406_ QYSES 411_ NHLHV 416_ DLWPF 421_ YPRNG 426_ VMTKD 431_ TWLDH 436_ RQDVE 441_ FPEHF 446_ LQPLV 451_ PLPFA 456_ GFVAQ 461_ APNNY 466_ RRFLE 471_ LKFGP 476_ GVIEN 481_ PQYPN 486_PALLS
1: Catalyzes the transfer of a ribitol 5-phosphate from CDP-L-ribitol to the ribitol 5-phosphate previously attached by FKTN/fukutin to the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:26923585, PubMed:27194101, PubMed:29477842, PubMed:31949166). This constitutes the second step in the formation of the ribose 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (PubMed:25279699, PubMed:26923585, PubMed:27194101, PubMed:29477842, PubMed:31949166)