Elongator complex protein 3 (hELP3) (EC 2.3.1.-) (tRNA uridine(34) acetyltransferase)
1_MRQKR 6_ KGDLS 11_ PAELM 16_ MLTIG 21_ DVIKQ 26_ LIEAH 31_ EQGKD 36_ IDLNK 41_ VKTKT 46_ AAKYG 51_ LSAQP 56_ RLVDI 61_ IAAVP 66_ PQYRK 71_ VLMPK 76_ LKAKP 81_ IRTAS 86_ GIAVV 91_ AVMCK 96_ PHRCP 101_ HISFT 106_ GNICV 111_ YCPGG 116_ PDSDF 121_ EYSTQ 126_ SYTGY 131_ EPTSM 136_ RAIRA 141_ RYDPF 146_ LQTRH 151_ RIEQL 156_ KQLGH 161_ SVDKV 166_ EFIVM 171_ GGTFM 176_ ALPEE 181_ YRDYF 186_ IRNLH 191_ DALSG 196_ HTSNN 201_ IYEAV 206_ KYSER 211_ SLTKC 216_ IGITI 221_ ETRPD 226_ YCMKR 231_ HLSDM 236_ LTYGC 241_ TRLEI 246_ GVQSV 251_ YEDVA 256_ RDTNR 261_ GHTVK 266_ AVCES 271_ FHLAK 276_ DSGFK 281_ VVAHM 286_ MPDLP 291_ NVGLE 296_ RDIEQ 301_ FTEFF 306_ ENPAF 311_ RPDGL 316_ KLYPT 321_ LVIRG 326_ TGLYE 331_ LWKSG 336_ RYKSY 341_ SPSDL 346_ VELVA 351_ RILAL 356_ VPPWT 361_ RVYRV 366_ QRDIP 371_ MPLVS 376_ SGVEH 381_ GNLRE 386_ LALAR 391_ MKDLG 396_ IQCRD 401_ VRTRE 406_ VGIQE 411_ IHHKV 416_ RPYQV 421_ ELVRR 426_ DYVAN 431_ GGWET 436_ FLSYE 441_ DPDQD 446_ ILIGL 451_ LRLRK 456_ CSEET 461_ FRFEL 466_ GGGVS 471_ IVREL 476_ HVYGS 481_ VVPVS 486_ SRDPT 491_ KFQHQ 496_ GFGML 501_ LMEEA 506_ ERIAR 511_ EEHGS 516_ GKIAV 521_ ISGVG 526_ TRNYY 531_ RKIGY 536_ RLQGP 541_YMVKM
1: Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29415125). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase (PubMed:29415125). Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:19185337). Required for acetylation of GJA1 in the developing cerebral cortex (By similarity)