Uridine-cytidine kinase 1 (UCK 1) (EC 2.7.1.48) (Cytidine monophosphokinase 1) (Uridine monophosphokinase 1)
1_MASAG 6_ GEDCE 11_ SPAPE 16_ ADRPH 21_ QRPFL 26_ IGVSG 31_ GTASG 36_ KSTVC 41_ EKIME 46_ LLGQN 51_ EVEQR 56_ QRKVV 61_ ILSQD 66_ RFYKV 71_ LTAEQ 76_ KAKAL 81_ KGQYN 86_ FDHPD 91_ AFDND 96_ LMHRT 101_ LKNIV 106_ EGKTV 111_ EVPTY 116_ DFVTH 121_ SRLPE 126_ TTVVY 131_ PADVV 136_ LFEGI 141_ LVFYS 146_ QEIRD 151_ MFHLR 156_ LFVDT 161_ DSDVR 166_ LSRRV 171_ LRDVR 176_ RGRDL 181_ EQILT 186_ QYTTF 191_ VKPAF 196_ EEFCL 201_ PTKKY 206_ ADVII 211_ PRGVD 216_ NMVAI 221_ NLIVQ 226_ HIQDI 231_ LNGDI 236_ CKWHR 241_ GGSNG 246_ RSYKR 251_ TFSEP 256_ GDHPG 261_ MLTSG 266_ KRSHL 271_ESSSR
1: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:11306702). Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702)