Phosphopantothenate--cysteine ligase (EC 6.3.2.51) (Phosphopantothenoylcysteine synthetase) (PPC synthetase)
1_MAEMD 6_ PVAEF 11_ PQPPG 16_ AARWA 21_ EVMAR 26_ FAARL 31_ GAQGR 36_ RVVLV 41_ TSGGT 46_ KVPLE 51_ ARPVR 56_ FLDNF 61_ SSGRR 66_ GATSA 71_ EAFLA 76_ AGYGV 81_ LFLYR 86_ ARSAF 91_ PYAHR 96_ FPPQT 101_ WLSAL 106_ RPSGP 111_ ALSGL 116_ LSLEA 121_ EENAL 126_ PGFAE 131_ ALRSY 136_ QEAAA 141_ AGTFL 146_ AVEFT 151_ TLADY 156_ LHLLQ 161_ AAAQA 166_ LNPLG 171_ PSAMF 176_ YLAAA 181_ VSDFY 186_ VPVSE 191_ MPEHK 196_ IQSSG 201_ GPLQI 206_ TMKMV 211_ PKLLS 216_ PLVKD 221_ WAPKA 226_ FIISF 231_ KLETD 236_ PAIVI 241_ NRARK 246_ ALEIY 251_ QHQVV 256_ VANIL 261_ ESRQS 266_ FVFIV 271_ TKDSE 276_ TKLLL 281_ SEEEI 286_ EKGVE 291_ IEEKI 296_ VDNLQ 301_ SRHTA 306_FIGDR
1: Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine (PubMed:11923312, PubMed:12906824, PubMed:29754768). Has a preference for ATP over CTP as a cosubstrate (PubMed:11923312)