Succinate--hydroxymethylglutarate CoA-transferase (EC 2.8.3.13) (Dermal papilla-derived protein 13) (SuccinylCoA:glutarate-CoA transferase)
1_MPSET 6_ HAMLA 11_ TLARV 16_ AALRR 21_ TCLFS 26_ GRGGG 31_ RGLWT 36_ GRPQS 41_ DMNNI 46_ KPLEG 51_ VKILD 56_ LTRVL 61_ AGPFA 66_ TMNLG 71_ DLGAE 76_ VIKVE 81_ RPGAG 86_ DDTRT 91_ WGPPF 96_ VGTES 101_ TYYLS 106_ VNRNK 111_ KSIAV 116_ NIKDP 121_ KGVKI 126_ IKELA 131_ AVCDV 136_ FVENY 141_ VPGKL 146_ SAMGL 151_ GYEDI 156_ DEIAP 161_ HIIYC 166_ SITGY 171_ GQTGP 176_ ISQRA 181_ GYDAV 186_ ASAVS 191_ GLMHI 196_ TGPEN 201_ GDPVR 206_ PGVAM 211_ TDLAT 216_ GLYAY 221_ GAIMA 226_ GLIQK 231_ YKTGK 236_ GLFID 241_ CNLLS 246_ SQVAC 251_ LSHIA 256_ ANYLI 261_ GQKEA 266_ KRWGT 271_ AHGSI 276_ VPYQA 281_ FKTKD 286_ GYIVV 291_ GAGNN 296_ QQFAT 301_ VCKIL 306_ DLPEL 311_ IDNSK 316_ YKTNH 321_ LRVHN 326_ RKELI 331_ KILSE 336_ RFEEE 341_ LTSKW 346_ LYLFE 351_ GSGVP 356_ YGPIN 361_ NMKNV 366_ FAEPQ 371_ VLHNG 376_ LVMEM 381_ EHPTV 386_ GKISV 391_ PGPAV 396_ RYSKF 401_ KMSEA 406_ RPPPL 411_ LGQHT 416_ THILK 421_ EVLRY 426_ DDRAI 431_ GELLS 436_AGVVD
1: Coenzyme A (CoA) transferase that reversibly catalyzes the transfer of a CoA moiety from a dicarboxyl-CoA to a dicarboxylate in a metabolite recycling process. Displays preference for succinyl-CoA and glutarate-CoA as dicarboxyl-CoA donors and glutarate, succinate, adipate/hexanedioate, itaconate and 3-hydroxy-3-methylglutarate as dicarboxylate acceptors (PubMed:23893049, PubMed:34492704, PubMed:38915184). Acts on intermediates or end products of lysine and tryptophan degradation pathway, in particular catalyzes succinyl-CoA-dependent reesterification of free glutarate into glutaryl-CoA to prevent renal excretion of glutarate (PubMed:18926513, PubMed:23893049, PubMed:38915184). Upon inflammation, may convert macrophage-derived itaconate to itaconyl-CoA in erythroid precursors where it negatively regulates the TCA cycle and heme synthesis to limit erythroid differentiation in the context of stress erythropoiesis (PubMed:34492704)