WD repeat-containing protein 41
1_MLRWL 6_ IGGGR 11_ EPQGL 16_ AEKSP 21_ LQTIG 26_ EEQTQ 31_ NPYTE 36_ LLVLK 41_ AHHDI 46_ VRFLV 51_ QLDDY 56_ RFASA 61_ GDDGI 66_ VVVWN 71_ AQTGE 76_ KLLEL 81_ NGHTQ 86_ KITAI 91_ ITFPS 96_ LESCE 101_ EKNQL 106_ ILTAS 111_ ADRTV 116_ IVWDG 121_ DTTRQ 126_ VQRIS 131_ CFQST 136_ VKCLT 141_ VLQRL 146_ DVWLS 151_ GGNDL 156_ CVWNR 161_ KLDLL 166_ CKTSH 171_ LSDTG 176_ ISALV 181_ EIPKN 186_ CVVAA 191_ VGKEL 196_ IIFRL 201_ VAPTE 206_ GSLEW 211_ DILEV 216_ KRLLD 221_ HQDNI 226_ LSLIN 231_ VNDLS 236_ FVTGS 241_ HVGEL 246_ IIWDA 251_ LDWTM 256_ QAYER 261_ NFWDP 266_ SPQLD 271_ TQQEI 276_ KLCQK 281_ SNDIS 286_ IHHFT 291_ CDEEN 296_ VFAAV 301_ GRGLY 306_ VYSLQ 311_ MKRVI 316_ ACQKT 321_ AHDSN 326_ VLHVA 331_ RLPNR 336_ QLISC 341_ SEDGS 346_ VRIWE 351_ LREKQ 356_ QLAAE 361_ PVPTG 366_ FFNMW 371_ GFGRV 376_ SKQAS 381_ QPVKK 386_ QQENA 391_ TSCSL 396_ ELIGD 401_ LIGHS 406_ SSVEM 411_ FLYFE 416_ DHGLV 421_ TCSAD 426_ HLIIL 431_ WKNGE 436_ RESGL 441_ RSLRL 446_ FQKLE 451_ENGDL
1: Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27103069, PubMed:27193190, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function (PubMed:32303654). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292)