Chromatin modification-related protein MEAF6 (MYST/Esa1-associated factor 6) (Esa1-associated factor 6 homolog) (Protein EAF6 homolog) (hEAF6) (Sarcoma antigen NY-SAR-91)
1_MAMHN 6_ KAAPP 11_ QIPDT 16_ RRELA 21_ ELVKR 26_ KQELA 31_ ETLAN 36_ LERQI 41_ YAFEG 46_ SYLED 51_ TQMYG 56_ NIIRG 61_ WDRYL 66_ TNQKN 71_ SNSKN 76_ DRRNR 81_ KFKEA 86_ ERLFS 91_ KSSVT 96_ SAAAV 101_ SALAG 106_ VQDQL 111_ IEKRE 116_ PGSGT 121_ ESDTS 126_ PDFHN 131_ QENEP 136_ SQEDP 141_ EDLDG 146_ SVQGV 151_ KPQKA 156_ ASSTS 161_ SGSHH 166_ SSHKK 171_ RKNKN 176_ RHRID 181_ LKLNK 186_KPRAD
1: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A (PubMed:14966270). This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653, PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:18794358)