TLR adapter interacting with SLC15A4 on the lysosome
1_MLSEG 6_ YLSGL 11_ EYWND 16_ IHWSC 21_ ASYNE 26_ QVAGE 31_ KEEET 36_ NSVAT 41_ LSYSS 46_ VDETQ 51_ VRSLY 56_ VSCKS 61_ SGKFI 66_ SSVHS 71_ RESQH 76_ SRSQR 81_ VTVLQ 86_ TNPNP 91_ VFESP 96_ NLAAV 101_ EICRD 106_ ASRET 111_ YLVPS 116_ SCKSI 121_ CKNYN 126_ DLQIA 131_ GGQVM 136_ AINSV 141_ TTDFP 146_ SESSF 151_ EYGPL 156_ LKSSE 161_ IPLPM 166_ EDSIS 171_ TQPSD 176_ FPQKP 181_ IQRYS 186_ SYWRI 191_ TSIKE 196_ KSSLQ 201_ MQNPI 206_ SNAVL 211_ NEYLE 216_ QKVVE 221_ LYKQY 226_ IMDTV 231_ FHDSS 236_ PTQIL 241_ ASELI 246_ MTSVD 251_ QISLQ 256_ VSREK 261_ NLETS 266_ KARDI 271_ VFSRL 276_ LQLMS 281_ TEITE 286_ ISTPS 291_ LHISQ 296_YSNVN
1: Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:32433612). Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons (PubMed:32433612). Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes (PubMed:31001245)