Histone deacetylase complex subunit SAP30L (HCV non-structural protein 4A-transactivated protein 2) (Sin3 corepressor complex subunit SAP30L) (Sin3-associated protein p30-like)
1_MNGFS 6_ TEEDS 11_ REGPP 16_ AAPAA 21_ AAPGY 26_ GQSCC 31_ LIEDG 36_ ERCVR 41_ PAGNA 46_ SFSKR 51_ VQKSI 56_ SQKKL 61_ KLDID 66_ KSVRH 71_ LYICD 76_ FHKNF 81_ IQSVR 86_ NKRKR 91_ KTSDD 96_ GGDSP 101_ EHDTD 106_ IPEVD 111_ LFQLQ 116_ VNTLR 121_ RYKRH 126_ YKLQT 131_ RPGFN 136_ KAQLA 141_ ETVSR 146_ HFRNI 151_ PVNEK 156_ ETLAY 161_ FIYMV 166_ KSNKS 171_ RLDQK 176_SEGGK
1: Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676)
2: Functions as a transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3
3: Functions as a transcription repressor; its activity is marginally lower than that of isoform 1