Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMN/NaMN adenylyltransferase 1) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide-nucleotide adenylyltransferase 1) (NMN adenylyltransferase 1) (Nicotinate-nucleotide adenylyltransferase 1) (NaMN adenylyltransferase 1)
1_MENSE 6_ KTEVV 11_ LLACG 16_ SFNPI 21_ TNMHL 26_ RLFEL 31_ AKDYM 36_ NGTGR 41_ YTVVK 46_ GIISP 51_ VGDAY 56_ KKKGL 61_ IPAYH 66_ RVIMA 71_ ELATK 76_ NSKWV 81_ EVDTW 86_ ESLQK 91_ EWKET 96_ LKVLR 101_ HHQEK 106_ LEASD 111_ CDHQQ 116_ NSPTL 121_ ERPGR 126_ KRKWT 131_ ETQDS 136_ SQKKS 141_ LEPKT 146_ KAVPK 151_ VKLLC 156_ GADLL 161_ ESFAV 166_ PNLWK 171_ SEDIT 176_ QIVAN 181_ YGLIC 186_ VTRAG 191_ NDAQK 196_ FIYES 201_ DVLWK 206_ HRSNI 211_ HVVNE 216_ WIAND 221_ ISSTK 226_ IRRAL 231_ RRGQS 236_ IRYLV 241_ PDLVQ 246_ EYIEK 251_ HNLYS 256_ SESED 261_ RNAGV 266_ ILAPL 271_QRNTA
1: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (PubMed:17402747). Can use triazofurin monophosphate (TrMP) as substrate (PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed:17402747). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (PubMed:17402747). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Also acts as a cofactor for glutamate and aspartate ADP-ribosylation by directing PARP1 catalytic activity to glutamate and aspartate residues on histones (By similarity). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:17402747). Protects against axonal degeneration following mechanical or toxic insults (By similarity). Neural protection does not correlate with cellular NAD(+) levels but may still require enzyme activity (By similarity)