Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2)
1_MAALV 6_ EPLGL 11_ ERDVS 16_ RAVEL 21_ LERLQ 26_ RSGEL 31_ PPQKL 36_ QALQR 41_ VLQSR 46_ FCSAI 51_ REVYE 56_ QLYDT 61_ LDITG 66_ SAEIR 71_ AHATA 76_ KATVA 81_ AFTAS 86_ EGHAH 91_ PRVVE 96_ LPKTD 101_ EGLGF 106_ NIMGG 111_ KEQNS 116_ PIYIS 121_ RVIPG 126_ GVADR 131_ HGGLK 136_ RGDQL 141_ LSVNG 146_ VSVEG 151_ EQHEK 156_ AVELL 161_ KAAQG 166_ SVKLV 171_ VRYTP 176_ RVLEE 181_ MEARF 186_ EKMRS 191_ ARRRQ 196_ QHQSY 201_SSLES
1: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity)