Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3)
1_MWPSQ 6_ LLIFM 11_ MLLAP 16_ IIHAF 21_ SRAPI 26_ PMAVV 31_ RRELS 36_ CESYP 41_ IELRC 46_ PGTDV 51_ IMIES 56_ ANYGR 61_ TDDKI 66_ CDSDP 71_ AQMEN 76_ IRCYL 81_ PDAYK 86_ IMSQR 91_ CNNRT 96_ QCAVV 101_ AGPDV 106_ FPDPC 111_ PGTYK 116_ YLEVQ 121_ YECVP 126_ YKVEQ 131_ KVFLC 136_ PGLLK 141_ GVYQS 146_ EHLFE 151_ SDHQS 156_ GAWCK 161_ DPLQA 166_ SDKIY 171_ YMPWT 176_ PYRTD 181_ TLTEY 186_ SSKDD 191_ FIAGR 196_ PTTTY 201_ KLPHR 206_ VDGTG 211_ FVVYD 216_ GALFF 221_ NKERT 226_ RNIVK 231_ FDLRT 236_ RIKSG 241_ EAIIA 246_ NANYH 251_ DTSPY 256_ RWGGK 261_ SDIDL 266_ AVDEN 271_ GLWVI 276_ YATEQ 281_ NNGKI 286_ VISQL 291_ NPYTL 296_ RIEGT 301_ WDTAY 306_ DKRSA 311_ SNAFM 316_ ICGIL 321_ YVVKS 326_ VYEDD 331_ DNEAT 336_ GNKID 341_ YIYNT 346_ DQSKD 351_ SLVDV 356_ PFPNS 361_ YQYIA 366_ AVDYN 371_ PRDNL 376_ LYVWN 381_ NYHVV 386_ KYSLD 391_ FGPLD 396_ SRSGQ 401_ AHHGQ 406_ VSYIS 411_ PPIHL 416_ DSELE 421_ RPSVK 426_ DISTT 431_ GPLGM 436_ GSTTT 441_ STTLR 446_ TTTLS 451_ PGRST 456_ TPSVS 461_ GRRNR 466_ STSTP 471_ SPAVE 476_ VLDDM 481_ TTHLP 486_ SASSQ 491_ IPALE 496_ ESCEA 501_ VEARE 506_ IMWFK 511_ TRQGQ 516_ IAKQP 521_ CPAGT 526_ IGVST 531_ YLCLA 536_ PDGIW 541_ DPQGP 546_ DLSNC 551_ SSPWV 556_ NHITQ 561_ KLKSG 566_ ETAAN 571_ IAREL 576_ AEQTR 581_ NHLNA 586_ GDITY 591_ SVRAM 596_ DQLVG 601_ LLDVQ 606_ LRNLT 611_ PGGKD 616_ SAARS 621_ LNKAM 626_ VETVN 631_ NLLQP 636_ QALNA 641_ WRDLT 646_ TSDQL 651_ RAATM 656_ LLHTV 661_ EESAF 666_ VLADN 671_ LLKTD 676_ IVREN 681_ TDNIK 686_ LEVAR 691_ LSTEG 696_ NLEDL 701_ KFPEN 706_ MGHGS 711_ TIQLS 716_ ANTLK 721_ QNGRN 726_ GEIRV 731_ AFVLY 736_ NNLGP 741_ YLSTE 746_ NASMK 751_ LGTEA 756_ LSTNH 761_ SVIVN 766_ SPVIT 771_ AAINK 776_ EFSNK 781_ VYLAD 786_ PVVFT 791_ VKHIK 796_ QSEEN 801_ FNPNC 806_ SFWSY 811_ SKRTM 816_ TGYWS 821_ TQGCR 826_ LLTTN 831_ KTHTT 836_ CSCNH 841_ LTNFA 846_ VLMAH 851_ VEVKH 856_ SDAVH 861_ DLLLD 866_ VITWV 871_ GILLS 876_ LVCLL 881_ ICIFT 886_ FCFFR 891_ GLQSD 896_ RNTIH 901_ KNLCI 906_ SLFVA 911_ ELLFL 916_ IGINR 921_ TDQPI 926_ ACAVF 931_ AALLH 936_ FFFLA 941_ AFTWM 946_ FLEGV 951_ QLYIM 956_ LVEVF 961_ ESEHS 966_ RRKYF 971_ YLVGY 976_ GMPAL 981_ IVAVS 986_ AAVDY 991_ RSYGT 996_ DKVCW 1001_ LRLDT 1006_ YFIWS 1011_ FIGPA 1016_ TLIIM 1021_ LNVIF 1026_ LGIAL 1031_ YKMFH 1036_ HTAIL 1041_ KPESG 1046_ CLDNI 1051_ KSWVI 1056_ GAIAL 1061_ LCLLG 1066_ LTWAF 1071_ GLMYI 1076_ NESTV 1081_ IMAYL 1086_ FTIFN 1091_ SLQGM 1096_ FIFIF 1101_ HCVLQ 1106_ KKVRK 1111_ EYGKC 1116_ LRTHC 1121_ CSGKS 1126_ TESSI 1131_ GSGKT 1136_ SGSRT 1141_ PGRYS 1146_ TGSQS 1151_ RIRRM 1156_ WNDTV 1161_ RKQSE 1166_ SSFIT 1171_ GDINS 1176_ SASLN 1181_ REGLL 1186_ NNARD 1191_ TSVMD 1196_ TLPLN 1201_ GNHGN 1206_ SYSIA 1211_ SGEYL 1216_ SNCVQ 1221_ IIDRG 1226_ YNHNE 1231_ TALEK 1236_ KILKE 1241_ LTSNY 1246_ IPSYL 1251_ NNHER 1256_ SSEQN 1261_ RNLMN 1266_ KLVNN 1271_ LGSGR 1276_ EDDAI 1281_ VLDDA 1286_ TSFNH 1291_ EESLG 1296_ LELIH 1301_ EESDA 1306_ PLLPP 1311_ RVYST 1316_ ENHQP 1321_ HHYTR 1326_ RRIPQ 1331_ DHSES 1336_ FFPLL 1341_ TNEHT 1346_ EDLQS 1351_ PHRDS 1356_ LYTSM 1361_ PTLAG 1366_ VAATE 1371_ SVTTS 1376_ TQTEP 1381_ PPAKC 1386_ GDAED 1391_ VYYKS 1396_ MPNLG 1401_ SRNHV 1406_ HQLHT 1411_ YYQLG 1416_ RGSSD 1421_ GFIVP 1426_ PNKDG 1431_ TPPEG 1436_ SSKGP 1441_AHLVT
1: Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (PubMed:35418682). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:35418682). ADGRL3 is coupled with different classes of G alpha proteins, such as G(12)/G(13), G(s), G(i) or G(q), depending on the context (PubMed:35418682). Coupling to G(12)/G(13) G proteins, which mediates the activation Rho small GTPases is the most efficient (PubMed:35418682). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity (PubMed:26235030). Specifically mediates the establishment of Schaffer-collateral synapses formed by CA3-region axons on CA1-region pyramidal neurons in the hippocampus (By similarity). Localizes to postsynaptic spines in excitatory synapses in the S.oriens and S.radiatum and interacts with presynaptic cell adhesion molecules FLRT3 and TENM2, promoting synapse formation (By similarity). Plays a role in the development of glutamatergic synapses in the cortex (By similarity). Important in determining the connectivity rates between the principal neurons in the cortex (By similarity)
2: Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. Isoform 1 is specifically coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Following G-protein coupled receptor activation, undergoes liquid-liquid phase transition, associates with (1) cell adhesion molecules that are expressed at the surface of adjacent cells, as well as (2) PDZ-containing proteins, such as SHANK3 and DLG4, in the cytoplasm to direct synapse formation