Sialate O-acetylesterase (EC 3.1.1.53) (H-Lse) (Sialic acid-specific 9-O-acetylesterase)
1_MVAPG 6_ LVLGL 11_ VLPLI 16_ LWADR 21_ SAGIG 26_ FRFAS 31_ YINND 36_ MVLQK 41_ EPAGA 46_ VIWGF 51_ GTPGA 56_ TVTVT 61_ LRQGQ 66_ ETIMK 71_ KVTSV 76_ KAHSD 81_ TWMVV 86_ LDPMK 91_ PGGPF 96_ EVMAQ 101_ QTLEK 106_ INFTL 111_ RVHDV 116_ LFGDV 121_ WLCSG 126_ QSNMQ 131_ MTVLQ 136_ IFNAT 141_ RELSN 146_ TAAYQ 151_ SVRIL 156_ SVSPI 161_ QAEQE 166_ LEDLV 171_ AVDLQ 176_ WSKPT 181_ SENLG 186_ HGYFK 191_ YMSAV 196_ CWLFG 201_ RHLYD 206_ TLQYP 211_ IGLIA 216_ SSWGG 221_ TPIEA 226_ WSSGR 231_ SLKAC 236_ GVPKQ 241_ GSIPY 246_ DSVTG 251_ PSKHS 256_ VLWNA 261_ MIHPL 266_ CNMTL 271_ KGVVW 276_ YQGES 281_ NINYN 286_ TDLYN 291_ CTFPA 296_ LIEDW 301_ RETFH 306_ RGSQG 311_ QTERF 316_ FPFGL 321_ VQLSS 326_ DLSKK 331_ SSDDG 336_ FPQIR 341_ WHQTA 346_ DFGYV 351_ PNPKM 356_ PNTFM 361_ AVAMD 366_ LCDRD 371_ SPFGS 376_ IHPRD 381_ KQTVA 386_ YRLHL 391_ GARAL 396_ AYGEK 401_ NLTFE 406_ GPLPE 411_ KIELL 416_ AHKGL 421_ LNLTY 426_ YQQIQ 431_ VQKKD 436_ NKIFE 441_ ISCCS 446_ DHRCK 451_ WLPAS 456_ MNTVS 461_ TQSLT 466_ LAIDS 471_ CHGTV 476_ VALRY 481_ AWTTW 486_ PCEYK 491_ QCPLY 496_ HPSSA 501_ LPAPP 506_ FIAFI 511_ TDQGP 516_GHQSN
1: Catalyzes the removal of O-acetyl ester groups from position 9 of the free diacetylated sialate N-acetyl-9-O-acetylneuraminate (Neu5,9Ac2) in the cytosol and of the diacetylated sialate residues of sialylglycoconjugates in the lysosomes (Probable). Together with the sialate-O-acetyltransferase they regulate the balance of acetylated sialoglycoconjugates, key players in various processes such as cell-cell interactions, host-pathogen recognition, and tumor antigenicity (PubMed:21803834)