E3 ubiquitin-protein ligase pellino homolog 2 (Pellino-2) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase pellino homolog 2)
1_MFSPG 6_ QEEHC 11_ APNKE 16_ PVKYG 21_ ELVVL 26_ GYNGA 31_ LPNGD 36_ RGRRK 41_ SRFAL 46_ YKRPK 51_ ANGVK 56_ PSTVH 61_ VISTP 66_ QASKA 71_ ISCKG 76_ QHSIS 81_ YTLSR 86_ NQTVV 91_ VEYTH 96_ DKDTD 101_ MFQVG 106_ RSTES 111_ PIDFV 116_ VTDTI 121_ SGSQN 126_ TDEAQ 131_ ITQST 136_ ISRFA 141_ CRIVC 146_ DRNEP 151_ YTARI 156_ FAAGF 161_ DSSKN 166_ IFLGE 171_ KAAKW 176_ KNPDG 181_ HMDGL 186_ TTNGV 191_ LVMHP 196_ RGGFT 201_ EESQP 206_ GVWRE 211_ ISVCG 216_ DVYTL 221_ RETRS 226_ AQQRG 231_ KLVES 236_ ETNVL 241_ QDGSL 246_ IDLCG 251_ ATLLW 256_ RTADG 261_ LFHTP 266_ TQKHI 271_ EALRQ 276_ EINAA 281_ RPQCP 286_ VGLNT 291_ LAFPS 296_ INRKE 301_ VVEEK 306_ QPWAY 311_ LSCGH 316_ VHGYH 321_ NWGHR 326_ SDTEA 331_ NEREC 336_ PMCRT 341_ VGPYV 346_ PLWLG 351_ CEAGF 356_ YVDAG 361_ PPTHA 366_ FTPCG 371_ HVCSE 376_ KSAKY 381_ WSQIP 386_ LPHGT 391_ HAFHA 396_ ACPFC 401_ ATQLV 406_ GEQNC 411_IKLIF
1: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1