Regulator of nonsense transcripts 2 (Up-frameshift suppressor 2 homolog) (hUpf2)
1_MPAER 6_ KKPAS 11_ MEEKD 16_ SLPNN 21_ KEKDC 26_ SERRT 31_ VSSKE 36_ RPKDD 41_ IKLTA 46_ KKEVS 51_ KAPED 56_ KKKRL 61_ EDDKR 66_ KKEDK 71_ ERKKK 76_ DEEKV 81_ KAEEE 86_ SKKKE 91_ EEEKK 96_ KHQEE 101_ ERKKQ 106_ EEQAK 111_ RQQEE 116_ EAAAQ 121_ MKEKE 126_ ESIQL 131_ HQEAW 136_ ERHHL 141_ RKELR 146_ SKNQN 151_ APDSR 156_ PEENF 161_ FSRLD 166_ SSLKK 171_ NTAFV 176_ KKLKT 181_ ITEQQ 186_ RDSLS 191_ HDFNG 196_ LNLSK 201_ YIAEA 206_ VASIV 211_ EAKLK 216_ ISDVN 221_ CAVHL 226_ CSLFH 231_ QRYAD 236_ FAPSL 241_ LQVWK 246_ KHFEA 251_ RKEEK 256_ TPNIT 261_ KLRTD 266_ LRFIA 271_ ELTIV 276_ GIFTD 281_ KEGLS 286_ LIYEQ 291_ LKNII 296_ NADRE 301_ SHTHV 306_ SVVIS 311_ FCRHC 316_ GDDIA 321_ GLVPR 326_ KVKSA 331_ AEKFN 336_ LSFPP 341_ SEIIS 346_ PEKQQ 351_ PFQNL 356_ LKEYF 361_ TSLTK 366_ HLKRD 371_ HRELQ 376_ NTERQ 381_ NRRIL 386_ HSKGE 391_ LSEDR 396_ HKQYE 401_ EFAMS 406_ YQKLL 411_ ANSQS 416_ LADLL 421_ DENMP 426_ DLPQD 431_ KPTPE 436_ EHGPG 441_ IDIFT 446_ PGKPG 451_ EYDLE 456_ GGIWE 461_ DEDAR 466_ NFYEN 471_ LIDLK 476_ AFVPA 481_ ILFKD 486_ NEKSC 491_ QNKES 496_ NKDDT 501_ KEAKE 506_ SKENK 511_ EVSSP 516_ DDLEL 521_ ELENL 526_ EINDD 531_ TLELE 536_ GGDEA 541_ EDLTK 546_ KLLDE 551_ QEQED 556_ EEAST 561_ GSHLK 566_ LIVDA 571_ FLQQL 576_ PNCVN 581_ RDLID 586_ KAAMD 591_ FCMNM 596_ NTKAN 601_ RKKLV 606_ RALFI 611_ VPRQR 616_ LDLLP 621_ FYARL 626_ VATLH 631_ PCMSD 636_ VAEDL 641_ CSMLR 646_ GDFRF 651_ HVRKK 656_ DQINI 661_ ETKNK 666_ TVRFI 671_ GELTK 676_ FKMFT 681_ KNDTL 686_ HCLKM 691_ LLSDF 696_ SHHHI 701_ EMACT 706_ LLETC 711_ GRFLF 716_ RSPES 721_ HLRTS 726_ VLLEQ 731_ MMRKK 736_ QAMHL 741_ DARYV 746_ TMVEN 751_ AYYYC 756_ NPPPA 761_ EKTVK 766_ KKRPP 771_ LQEYV 776_ RKLLY 781_ KDLSK 786_ VTTEK 791_ VLRQM 796_ RKLPW 801_ QDQEV 806_ KDYVI 811_ CCMIN 816_ IWNVK 821_ YNSIH 826_ CVANL 831_ LAGLV 836_ LYQED 841_ VGIHV 846_ VDGVL 851_ EDIRL 856_ GMEVN 861_ QPKFN 866_ QRRIS 871_ SAKFL 876_ GELYN 881_ YRMVE 886_ SAVIF 891_ RTLYS 896_ FTSFG 901_ VNPDG 906_ SPSSL 911_ DPPEH 916_ LFRIR 921_ LVCTI 926_ LDTCG 931_ QYFDR 936_ GSSKR 941_ KLDCF 946_ LVYFQ 951_ RYVWW 956_ KKSLE 961_ VWTKD 966_ HPFPI 971_ DIDYM 976_ ISDTL 981_ ELLRP 986_ KIKLC 991_ NSLEE 996_ SIRQV 1001_ QDLER 1006_ EFLIK 1011_ LGLVN 1016_ DKDSK 1021_ DSMTE 1026_ GENLE 1031_ EDEEE 1036_ EEGGA 1041_ ETEEQ 1046_ SGNES 1051_ EVNEP 1056_ EEEEG 1061_ SDNDD 1066_ DEGEE 1071_ EEEEN 1076_ TDYLT 1081_ DSNKE 1086_ NETDE 1091_ ENTEV 1096_ MIKGG 1101_ GLKHV 1106_ PCVED 1111_ EDFIQ 1116_ ALDKM 1121_ MLENL 1126_ QQRSG 1131_ ESVKV 1136_ HQLDV 1141_ AIPLH 1146_ LKSQL 1151_ RKGPP 1156_ LGGGE 1161_ GEAES 1166_ ADTMP 1171_ FVMLT 1176_ RKGNK 1181_ QQFKI 1186_ LNVPM 1191_ SSQLA 1196_ ANHWN 1201_ QQQAE 1206_ QEERM 1211_ RMKKL 1216_ TLDIN 1221_ ERQEQ 1226_ EDYQE 1231_ MLQSL 1236_ AQRPA 1241_ PANTN 1246_ RERRP 1251_ RYQHP 1256_ KGAPN 1261_ ADLIF 1266_KTGGR
1: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA