Exportin-5 (Exp5) (Ran-binding protein 21)
1_MAMDQ 6_ VNALC 11_ EQLVK 16_ AVTVM 21_ MDPNS 26_ TQRYR 31_ LEALK 36_ FCEEF 41_ KEKCP 46_ ICVPC 51_ GLRLA 56_ EKTQV 61_ AIVRH 66_ FGLQI 71_ LEHVV 76_ KFRWN 81_ GMSRL 86_ EKVYL 91_ KNSVM 96_ ELIAN 101_ GTLNI 106_ LEEEN 111_ HIKDA 116_ LSRIV 121_ VEMIK 126_ REWPQ 131_ HWPDM 136_ LIELD 141_ TLSKQ 146_ GETQT 151_ ELVMF 156_ ILLRL 161_ AEDVV 166_ TFQTL 171_ PPQRR 176_ RDIQQ 181_ TLTQN 186_ MERIF 191_ SFLLN 196_ TLQEN 201_ VNKYQ 206_ QVKTD 211_ TSQES 216_ KAQAN 221_ CRVGV 226_ AALNT 231_ LAGYI 236_ DWVSM 241_ SHITA 246_ ENCKL 251_ LEILC 256_ LLLNE 261_ QELQL 266_ GAAEC 271_ LLIAV 276_ SRKGK 281_ LEDRK 286_ PLMVL 291_ FGDVA 296_ MHYIL 301_ SAAQT 306_ ADGGG 311_ LVEKH 316_ YVFLK 321_ RLCQV 326_ LCALG 331_ NQLCA 336_ LLGAD 341_ SDVET 346_ PSNFG 351_ KYLES 356_ FLAFT 361_ THPSQ 366_ FLRSS 371_ TQMTW 376_ GALFR 381_ HEILS 386_ RDPLL 391_ LAIIP 396_ KYLRA 401_ SMTNL 406_ VKMGF 411_ PSKTD 416_ SPSCE 421_ YSRFD 426_ FDSDE 431_ DFNAF 436_ FNSSR 441_ AQQGE 446_ VMRLA 451_ CRLDP 456_ KTSFQ 461_ MAGEW 466_ LKYQL 471_ STFLD 476_ AGSVN 481_ SCSAV 486_ GTGEG 491_ SLCSV 496_ FSPSF 501_ VQWEA 506_ MTLFL 511_ ESVIT 516_ QMFRT 521_ LNREE 526_ IPVND 531_ GIELL 536_ QMVLN 541_ FDTKD 546_ PLILS 551_ CVLTN 556_ VSALF 561_ PFVTY 566_ RPEFL 571_ PQVFS 576_ KLFSS 581_ VTFET 586_ VEESK 591_ APRTR 596_ AVRNV 601_ RRHAC 606_ SSIIK 611_ MCRDY 616_ PQLVL 621_ PNFDM 626_ LYNHV 631_ KQLLS 636_ NELLL 641_ TQMEK 646_ CALME 651_ ALVLI 656_ SNQFK 661_ NYERQ 666_ KVFLE 671_ ELMAP 676_ VASIW 681_ LSQDM 686_ HRVLS 691_ DVDAF 696_ IAYVG 701_ TDQKS 706_ CDPGL 711_ EDPCG 716_ LNRAR 721_ MSFCV 726_ YSILG 731_ VVKRT 736_ CWPTD 741_ LEEAK 746_ AGGFV 751_ VGYTS 756_ SGNPI 761_ FRNPC 766_ TEQIL 771_ KLLDN 776_ LLALI 781_ RTHNT 786_ LYAPE 791_ MLAKM 796_ AEPFT 801_ KALDM 806_ LDAEK 811_ SAILG 816_ LPQPL 821_ LELND 826_ SPVFK 831_ TVLER 836_ MQRFF 841_ STLYE 846_ NCFHI 851_ LGKAG 856_ PSMQQ 861_ DFYTV 866_ EDLAT 871_ QLLSS 876_ AFVNL 881_ NNIPD 886_ YRLRP 891_ MLRVF 896_ VKPLV 901_ LFCPP 906_ EHYEA 911_ LVSPI 916_ LGPLF 921_ TYLHM 926_ RLSQK 931_ WQVIN 936_ QRSLL 941_ CGEDE 946_ AADEN 951_ PESQE 956_ MLEEQ 961_ LVRML 966_ TREVM 971_ DLITV 976_ CCVSK 981_ KGADH 986_ SSAPP 991_ ADGDD 996_ EEMMA 1001_ TEVTP 1006_ SAMAE 1011_ LTDLG 1016_ KCLMK 1021_ HEDVC 1026_ TALLI 1031_ TAFNS 1036_ LAWKD 1041_ TLSCQ 1046_ RTTSQ 1051_ LCWPL 1056_ LKQVL 1061_ SGTLL 1066_ ADAVT 1071_ WLFTS 1076_ VLKGL 1081_ QMHGQ 1086_ HDGCM 1091_ ASLVH 1096_ LAFQI 1101_ YEALR 1106_ PRYLE 1111_ IRAVM 1116_ EQIPE 1121_ IQKDS 1126_ LDQFD 1131_ CKLLN 1136_ PSLQK 1141_ VADKR 1146_ RKDQF 1151_ KRLIA 1156_ GCIGK 1161_ PLGEQ 1166_ FRKEV 1171_ HIKNL 1176_ PSLFK 1181_ KTKPM 1186_ LETEV 1191_ LDNDG 1196_GGLAT
1: Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner
2: Mediates the nuclear export of micro-RNA precursors, which form short hairpins (PubMed:14631048, PubMed:14681208, PubMed:15613540). Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs (PubMed:19965479). Binding is dependent on Ran-GTP (PubMed:19965479)
3: (Microbial infection) Mediates the nuclear export of adenovirus VA1 dsRNA