Claspin (hClaspin)
1_MTGEV 6_ GSEVH 11_ LEIND 16_ PNVIS 21_ QEEAD 26_ SPSDS 31_ GQGSY 36_ ETIGP 41_ LSEGD 46_ SDEEI 51_ FVSKK 56_ LKNRK 61_ VLQDS 66_ DSETE 71_ DTNAS 76_ PEKTT 81_ YDSAE 86_ EENKE 91_ NLYAG 96_ KNTKI 101_ KRIYK 106_ TVADS 111_ DESYM 116_ EKSLY 121_ QENLE 126_ AQVKP 131_ CLELS 136_ LQSGN 141_ STDFT 146_ TDRKS 151_ SKKHI 156_ HDKEG 161_ TAGKA 166_ KVKSK 171_ RRLEK 176_ EERKM 181_ EKIRQ 186_ LKKKE 191_ TKNQE 196_ DDVEQ 201_ PFNDS 206_ GCLLV 211_ DKDLF 216_ ETGLE 221_ DENNS 226_ PLEDE 231_ ESLES 236_ IRAAV 241_ KNKVK 246_ KHKKK 251_ EPSLE 256_ SGVHS 261_ FEEGS 266_ ELSKG 271_ TTRKE 276_ RKAAR 281_ LSKEA 286_ LKQLH 291_ SETQR 296_ LIRES 301_ ALNLP 306_ YHMPE 311_ NKTIH 316_ DFFKR 321_ KPRPT 326_ CHGNA 331_ MALLK 336_ SSKYQ 341_ SSHHK 346_ EIIDT 351_ ANTTE 356_ MNSDH 361_ HSKGS 366_ EQTTG 371_ AENEV 376_ ETNAL 381_ PVVSK 386_ ETQII 391_ TGSDE 396_ SCRKD 401_ LVKNE 406_ ELEIQ 411_ EKQKQ 416_ SDIRP 421_ SPGDS 426_ SVLQQ 431_ ESNFL 436_ GNNHS 441_ EECQV 446_ GGLVA 451_ FEPHA 456_ LEGEG 461_ PQNPE 466_ ETDEK 471_ VEEPE 476_ QQNKS 481_ SAVGP 486_ PEKVR 491_ RFTLD 496_ RLKQL 501_ GVDVS 506_ IKPRL 511_ GADED 516_ SFVIL 521_ EPETN 526_ RELEA 531_ LKQRF 536_ WKHAN 541_ PAAKP 546_ RAGQT 551_ VNVNV 556_ IVKDM 561_ GTDGK 566_ EELKA 571_ DVVPV 576_ TLAPK 581_ KLDGA 586_ SHTKP 591_ GEKLQ 596_ VLKAK 601_ LQEAM 606_ KLRRF 611_ EERQK 616_ RQALF 621_ KLDNE 626_ DGFEE 631_ EEEEE 636_ EEMTD 641_ ESEED 646_ GEEKV 651_ EKEEK 656_ EEELE 661_ EEEEK 666_ EEEEE 671_ EEGNQ 676_ ETAEF 681_ LLSSE 686_ EIETK 691_ DEKEM 696_ DKENN 701_ DGSSE 706_ IGKAV 711_ GFLSV 716_ PKSLS 721_ SDSTL 726_ LLFKD 731_ SSSKM 736_ GYFPT 741_ EEKSE 746_ TDENS 751_ GKQPS 756_ KLDED 761_ DSCSL 766_ LTKES 771_ SHNSS 776_ FELIG 781_ STIPS 786_ YQPCN 791_ RQTGR 796_ GTSFF 801_ PTAGG 806_ FRSPS 811_ PGLFR 816_ ASLVS 821_ SASKS 826_ SGKLS 831_ EPSLP 836_ IEDSQ 841_ DLYNA 846_ SPEPK 851_ TLFLG 856_ AGDFQ 861_ FCLED 866_ DTQSQ 871_ LLDAD 876_ GFLNV 881_ RNHRN 886_ QYQAL 891_ KPRLP 896_ LASMD 901_ ENAMD 906_ ANMDE 911_ LLDLC 916_ TGKFT 921_ SQAEK 926_ HLPRK 931_ SDKKE 936_ NMEEL 941_ LNLCS 946_ GKFTS 951_ QDAST 956_ PASSE 961_ LNKQE 966_ KESSM 971_ GDPME 976_ EALAL 981_ CSGSF 986_ PTDKE 991_ EEDEE 996_ EEFGD 1001_ FRLVS 1006_ NDNEF 1011_ DSDED 1016_ EHSDS 1021_ GNDLA 1026_ LEDHE 1031_ DDDEE 1036_ ELLKR 1041_ SEKLK 1046_ RQMRL 1051_ RKYLE 1056_ DEAEV 1061_ SGSDV 1066_ GSEDE 1071_ YDGEE 1076_ IDEYE 1081_ EDVID 1086_ EVLPS 1091_ DEELQ 1096_ SQIKK 1101_ IHMKT 1106_ MLDDD 1111_ KRQLR 1116_ LYQER 1121_ YLADG 1126_ DLHSD 1131_ GPGRM 1136_ RKFRW 1141_ KNIDD 1146_ ASQMD 1151_ LFHRD 1156_ SDDDQ 1161_ TEEQL 1166_ DESEA 1171_ RWRKE 1176_ RIERE 1181_ QWLRD 1186_ MAQQG 1191_ KITAE 1196_ EEEEI 1201_ GEDSQ 1206_ FMILA 1211_ KKVTA 1216_ KALQK 1221_ NASRP 1226_ MVIQE 1231_ SKSLL 1236_ RNPFE 1241_ AIRPG 1246_ SAQQV 1251_ KTGSL 1256_ LNQPK 1261_ AVLQK 1266_ LAALS 1271_ DHNPS 1276_ APRNS 1281_ RNFVF 1286_ HTLSP 1291_ VKAEA 1296_ AKESS 1301_ KSQVK 1306_ KRGPS 1311_ FMTSP 1316_ SPKHL 1321_ KTDDS 1326_ TSGLT 1331_RSIFK
1: Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717)