UDP-glucuronosyltransferase 1A8 (UGT1A8) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-8) (UDPGT 1-8) (UGT1*8) (UGT1-08) (UGT1.8) (UDP-glucuronosyltransferase 1-H) (UGT-1H) (UGT1H)
1_MARTG 6_ WTSPI 11_ PLCVS 16_ LLLTC 21_ GFAEA 26_ GKLLV 31_ VPMDG 36_ SHWFT 41_ MQSVV 46_ EKLIL 51_ RGHEV 56_ VVVMP 61_ EVSWQ 66_ LGKSL 71_ NCTVK 76_ TYSTS 81_ YTLED 86_ LDREF 91_ MDFAD 96_ AQWKA 101_ QVRSL 106_ FSLFL 111_ SSSNG 116_ FFNLF 121_ FSHCR 126_ SLFND 131_ RKLVE 136_ YLKES 141_ SFDAV 146_ FLDPF 151_ DACGL 156_ IVAKY 161_ FSLPS 166_ VVFAR 171_ GIACH 176_ YLEEG 181_ AQCPA 186_ PLSYV 191_ PRILL 196_ GFSDA 201_ MTFKE 206_ RVRNH 211_ IMHLE 216_ EHLFC 221_ QYFSK 226_ NALEI 231_ ASEIL 236_ QTPVT 241_ AYDLY 246_ SHTSI 251_ WLLRT 256_ DFVLD 261_ YPKPV 266_ MPNMI 271_ FIGGI 276_ NCHQG 281_ KPLPM 286_ EFEAY 291_ INASG 296_ EHGIV 301_ VFSLG 306_ SMVSE 311_ IPEKK 316_ AMAIA 321_ DALGK 326_ IPQTV 331_ LWRYT 336_ GTRPS 341_ NLANN 346_ TILVK 351_ WLPQN 356_ DLLGH 361_ PMTRA 366_ FITHA 371_ GSHGV 376_ YESIC 381_ NGVPM 386_ VMMPL 391_ FGDQM 396_ DNAKR 401_ METKG 406_ AGVTL 411_ NVLEM 416_ TSEDL 421_ ENALK 426_ AVIND 431_ KSYKE 436_ NIMRL 441_ SSLHK 446_ DRPVE 451_ PLDLA 456_ VFWVE 461_ FVMRH 466_ KGAPH 471_ LRPAA 476_ HDLTW 481_ YQYHS 486_ LDVIG 491_ FLLAV 496_ VLTVA 501_ FITFK 506_ CCAYG 511_ YRKCL 516_ GKKGR 521_VKKAH
1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:16595710, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:18719240, PubMed:19545173, PubMed:23288867, PubMed:21422672). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:15472229, PubMed:16595710, PubMed:23288867). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens and estrogens (PubMed:15472229, PubMed:16595710, PubMed:18719240, PubMed:23288867). Produces dihydrotestosterone (DHT) diglucuronide from the DHT after two subsequent glucoronidation steps (PubMed:16595710). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group (PubMed:21422672). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161, PubMed:18004212)
2: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1