Melanoma-associated antigen F1 (MAGE-F1) (MAGE-F1 antigen)
1_MLQTP 6_ ESRGL 11_ PVPQA 16_ EGEKD 21_ GGHDG 26_ ETRAP 31_ TASQE 36_ RPKEE 41_ LGAGR 46_ EEGAA 51_ EPALT 56_ RKGAR 61_ ALAAK 66_ ALARR 71_ RAYRR 76_ LNRTV 81_ AELVQ 86_ FLLVK 91_ DKKKS 96_ PITRS 101_ EMVKY 106_ VIGDL 111_ KILFP 116_ DIIAR 121_ AAEHL 126_ RYVFG 131_ FELKQ 136_ FDRKH 141_ HTYIL 146_ INKLK 151_ PLEEE 156_ EEEDL 161_ GGDGP 166_ RLGLL 171_ MMILG 176_ LIYMR 181_ GNSAR 186_ EAQVW 191_ EMLRR 196_ LGVQP 201_ SKYHF 206_ LFGYP 211_ KRLIM 216_ EDFVQ 221_ QRYLS 226_ YRRVP 231_ HTNPP 236_ EYEFS 241_ WGPRS 246_ NLEIS 251_ KMEVL 256_ GFVAK 261_ LHKKE 266_ PQHWP 271_ VQYRE 276_ ALADE 281_ ADRAR 286_ AKARA 291_ EASMR 296_ ARASA 301_RAGIH
1: Enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. MAGEF1-NSMCE1 ubiquitin ligase complex promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. May negatively regulate genome integrity by inhibiting homologous recombination-mediated double-strand break DNA repair (PubMed:29225034)