Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4)
1_MRHSK 6_ RTHCP 11_ DWDSR 16_ ESWGH 21_ ESYRG 26_ SHKRK 31_ RRSHS 36_ STQEN 41_ RHCKP 46_ HHQFK 51_ ESDCH 56_ YLEAR 61_ SLNER 66_ DYRDR 71_ RYVDE 76_ YRNDY 81_ CEGYV 86_ PRHYH 91_ RDIES 96_ GYRIH 101_ CSKSS 106_ VRSRR 111_ SSPKR 116_ KRNRH 121_ CSSHQ 126_ SRSKS 131_ HRRKR 136_ SRSIE 141_ DDEEG 146_ HLICQ 151_ SGDVL 156_ RARYE 161_ IVDTL 166_ GEGAF 171_ GKVVE 176_ CIDHG 181_ MDGMH 186_ VAVKI 191_ VKNVG 196_ RYREA 201_ ARSEI 206_ QVLEH 211_ LNSTD 216_ PNSVF 221_ RCVQM 226_ LEWFD 231_ HHGHV 236_ CIVFE 241_ LLGLS 246_ TYDFI 251_ KENSF 256_ LPFQI 261_ DHIRQ 266_ MAYQI 271_ CQSIN 276_ FLHHN 281_ KLTHT 286_ DLKPE 291_ NILFV 296_ KSDYV 301_ VKYNS 306_ KMKRD 311_ ERTLK 316_ NTDIK 321_ VVDFG 326_ SATYD 331_ DEHHS 336_ TLVST 341_ RHYRA 346_ PEVIL 351_ ALGWS 356_ QPCDV 361_ WSIGC 366_ ILIEY 371_ YLGFT 376_ VFQTH 381_ DSKEH 386_ LAMME 391_ RILGP 396_ IPQHM 401_ IQKTR 406_ KRKYF 411_ HHNQL 416_ DWDEH 421_ SSAGR 426_ YVRRR 431_ CKPLK 436_ EFMLC 441_ HDEEH 446_ EKLFD 451_ LVRRM 456_ LEYDP 461_ TQRIT 466_ LDEAL 471_ QHPFF 476_DLLKK
1: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells