Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1)
1_MRSKA 6_ RARKL 11_ AKSDG 16_ DVVNN 21_ MYEPN 26_ RDLLA 31_ SHSAE 36_ DEAED 41_ SAMSP 46_ IPVGP 51_ PSPFP 56_ TSEDF 61_ TPKEG 66_ SPYEA 71_ PVYIP 76_ EDIPI 81_ PADFE 86_ LRESS 91_ IPGAG 96_ LGVWA 101_ KRKME 106_ AGERL 111_ GPCVV 116_ VPRAA 121_ AKETD 126_ FGWEQ 131_ ILTDV 136_ EVSPQ 141_ EGCIT 146_ KISED 151_ LGSEK 156_ FCVDA 161_ NQAGA 166_ GSWLK 171_ YIRVA 176_ CSCDD 181_ QNLTM 186_ CQISE 191_ QIYYK 196_ VIKDI 201_ EPGEE 206_ LLVHV 211_ KEGVY 216_ PLGTV 221_ PPGLD 226_ EEPTF 231_ RCDEC 236_ DELFQ 241_ SKLDL 246_ RRHKK 251_ YTCGS 256_ VGAAL 261_ YEGLA 266_ EELKP 271_ EGLGG 276_ GSGQA 281_ HECKD 286_ CERMF 291_ PNKYS 296_ LEQHM 301_ VIHTE 306_ EREYK 311_ CDQCP 316_ KAFNW 321_ KSNLI 326_ RHQMS 331_ HDSGK 336_ RFECE 341_ NCVKV 346_ FTDPS 351_ NLQRH 356_ IRSQH 361_ VGARA 366_ HACPD 371_ CGKTF 376_ ATSSG 381_ LKQHK 386_ HIHST 391_ VKPFI 396_ CEVCH 401_ KSYTQ 406_ FSNLC 411_ RHKRM 416_ HADCR 421_ TQIKC 426_ KDCGQ 431_ MFSTT 436_ SSLNK 441_ HRRFC 446_ EGKNH 451_ YTPGG 456_ IFAPG 461_ LPLTP 466_ SPMMD 471_ KAKPS 476_ PSLNH 481_ ASLGF 486_ NEYFP 491_ SRPHP 496_ GSLPF 501_ STAPP 506_ TFPAL 511_ TPGFP 516_ GIFPP 521_ SLYPR 526_ PPLLP 531_ PTSLL 536_ KSPLN 541_ HTQDA 546_ KLPSP 551_ LGNPA 556_ LPLVS 561_ AVSNS 566_ SQGTT 571_ AAAGP 576_ EEKFE 581_ SRLED 586_ SCVEK 591_ LKTRS 596_ SDMSD 601_ GSDFE 606_ DVNTT 611_ TGTDL 616_ DTTTG 621_ TGSDL 626_ DSDVD 631_ SDPDK 636_ DKGKG 641_ KSAEG 646_ QPKFG 651_ GGLAP 656_ PGAPN 661_ SVAEV 666_ PVFYS 671_ QHSFF 676_ PPPDE 681_ QLLTA 686_ TGAAG 691_ DSIKA 696_ IASIA 701_ EKYFG 706_ PGFMG 711_ MQEKK 716_ LGSLP 721_ YHSAF 726_ PFQFL 731_ PNFPH 736_ SLYPF 741_ TDRAL 746_ AHNLL 751_ VKAEP 756_ KSPRD 761_ ALKVG 766_ GPSAE 771_ CPFDL 776_ TTKPK 781_ DVKPI 786_ LPMPK 791_ GPSAP 796_ ASGEE 801_ QPLDL 806_ SIGSR 811_ ARASQ 816_ NGGGR 821_ EPRKN 826_ HVYGE 831_ RKLGA 836_ GEGLP 841_ QVCPA 846_ RMPQQ 851_ PPLHY 856_ AKPSP 861_ FFMDP 866_ IYSRV 871_ EKRKV 876_ TDPVG 881_ ALKEK 886_ YLRPS 891_ PLLFH 896_ PQMSA 901_ IETMT 906_ EKLES 911_ FAAMK 916_ ADSGS 921_ SLQPL 926_ PHHPF 931_ NFRSP 936_ PPTLS 941_ DPILR 946_ KGKER 951_ YTCRY 956_ CGKIF 961_ PRSAN 966_ LTRHL 971_ RTHTG 976_ EQPYR 981_ CKYCD 986_ RSFSI 991_ SSNLQ 996_ RHVRN 1001_ IHNKE 1006_ KPFKC 1011_ HLCNR 1016_ CFGQQ 1021_ TNLDR 1026_ HLKKH 1031_ EHENA 1036_ PVSQH 1041_ PGVLT 1046_ NHLGT 1051_ SASSP 1056_ TSESD 1061_ NHALL 1066_ DEKED 1071_ SYFSE 1076_ IRNFI 1081_ ANSEM 1086_ NQAST 1091_ RTEKR 1096_ ADMQI 1101_ VDGSA 1106_ QCPGL 1111_ ASEKQ 1116_ EDVEE 1121_ EDDDD 1126_ LEEDD 1131_ EDSLA 1136_ GKSQD 1141_ DTVSP 1146_ APEPQ 1151_ AAYED 1156_ EEDEE 1161_ PAASL 1166_ AVGFD 1171_ HTRRC 1176_ AEDHE 1181_ GGLLA 1186_ LEPMP 1191_ TFGKG 1196_ LDLRR 1201_ AAEEA 1206_ FEVKD 1211_ VLNST 1216_ LDSEA 1221_ LKHTL 1226_ CRQAK 1231_ NQAYA 1236_ MMLSL 1241_ SEDTP 1246_ LHTPS 1251_ QGSLD 1256_ AWLKV 1261_ TGATS 1266_ ESGAF 1271_HPINH
1: Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling (PubMed:19049980)
2: Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Functions as a repressor of TGF-beta signaling (PubMed:14656887). May regulate granulocyte differentiation (PubMed:12816872)