Elongation of very long chain fatty acids protein 3 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL3) (Cold-inducible glycoprotein of 30 kDa) (ELOVL fatty acid elongase 3) (ELOVL FA elongase 3) (Very long chain 3-ketoacyl-CoA synthase 3) (Very long chain 3-oxoacyl-CoA synthase 3)
1_MVTAM 6_ NVSHE 11_ VNQLF 16_ QPYNF 21_ ELSKD 26_ MRPFF 31_ EEYWA 36_ TSFPI 41_ ALIYL 46_ VLIAV 51_ GQNYM 56_ KERKG 61_ FNLQG 66_ PLILW 71_ SFCLA 76_ IFSIL 81_ GAVRM 86_ WGIMG 91_ TVLLT 96_ GGLKQ 101_ TVCFI 106_ NFIDN 111_ STVKF 116_ WSWVF 121_ LLSKV 126_ IELGD 131_ TAFII 136_ LRKRP 141_ LIFIH 146_ WYHHS 151_ TVLVY 156_ TSFGY 161_ KNKVP 166_ AGGWF 171_ VTMNF 176_ GVHAI 181_ MYTYY 186_ TLKAA 191_ NVKPP 196_ KMLPM 201_ LITSL 206_ QILQM 211_ FVGAI 216_ VSILT 221_ YIWRQ 226_ DQGCH 231_ TTMEH 236_ LFWSF 241_ ILYMT 246_ YFILF 251_ AHFFC 256_ QTYIR 261_PKVKA
1: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators