MYG1 exonuclease (EC 3.1.-.-)
1_MGHRF 6_ LRGLL 11_ TLLLP 16_ PPPLY 21_ TRHRM 26_ LGPES 31_ VPPPK 36_ RSRSK 41_ LMAPP 46_ RIGTH 51_ NGTFH 56_ CDEAL 61_ ACALL 66_ RLLPE 71_ YRDAE 76_ IVRTR 81_ DPEKL 86_ ASCDI 91_ VVDVG 96_ GEYDP 101_ RRHRY 106_ DHHQR 111_ SFTET 116_ MSSLS 121_ PGKPW 126_ QTKLS 131_ SAGLI 136_ YLHFG 141_ HKLLA 146_ QLLGT 151_ SEEDS 156_ MVGTL 161_ YDKMY 166_ ENFVE 171_ EVDAV 176_ DNGIS 181_ QWAEG 186_ EPRYA 191_ LTTTL 196_ SARVA 201_ RLNPT 206_ WNHPD 211_ QDTEA 216_ GFKRA 221_ MDLVQ 226_ EEFLQ 231_ RLDFY 236_ QHSWL 241_ PARAL 246_ VEEAL 251_ AQRFQ 256_ VDPSG 261_ EIVEL 266_ AKGAC 271_ PWKEH 276_ LYHLE 281_ SGLSP 286_ PVAIF 291_ FVIYT 296_ DQAGQ 301_ WRIQC 306_ VPKEP 311_ HSFQS 316_ RLPLP 321_ EPWRG 326_ LRDEA 331_ LDQVS 336_ GIPGC 341_ IFVHA 346_ SGFTG 351_ GHHTR 356_ EGALS 361_ MARAT 366_ LAQRS 371_YLPQI
1: 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable)