Potassium channel subfamily K member 13 (Tandem pore domain halothane-inhibited potassium channel 1) (THIK-1)
1_MAGRG 6_ FSWGP 11_ GHLNE 16_ DNARF 21_ LLLAA 26_ LIVLY 31_ LLGGA 36_ AVFSA 41_ LELAH 46_ ERQAK 51_ QRWEE 56_ RLANF 61_ SRGHN 66_ LSRDE 71_ LRGFL 76_ RHYEE 81_ ATRAG 86_ IRVDN 91_ VRPRW 96_ DFTGA 101_ FYFVG 106_ TVVST 111_ IGFGM 116_ TTPAT 121_ VGGKI 126_ FLIFY 131_ GLVGC 136_ SSTIL 141_ FFNLF 146_ LERLI 151_ TIIAY 156_ IMKSC 161_ HQRQL 166_ RRRGA 171_ LPQES 176_ LKDAG 181_ QCEVD 186_ SLAGW 191_ KPSVY 196_ YVMLI 201_ LCTAS 206_ ILISC 211_ CASAM 216_ YTPIE 221_ GWSYF 226_ DSLYF 231_ CFVAF 236_ STIGF 241_ GDLVS 246_ SQNAH 251_ YESQG 256_ LYRFA 261_ NFVFI 266_ LMGVC 271_ CIYSL 276_ FNVIS 281_ ILIKQ 286_ SLNWI 291_ LRKMD 296_ SGCCP 301_ QCQRG 306_ LLRSR 311_ RNVVM 316_ PGSVR 321_ NRCNI 326_ SIETD 331_ GVAES 336_ DTDGR 341_ RLSGE 346_ MISMK 351_ DLLAA 356_ NKASL 361_ AILQK 366_ QLSEM 371_ ANGCP 376_ HQTST 381_ LARDN 386_ EFSGG 391_ VGAFA 396_ IMNNR 401_LAETS
1: K(+) channel that conducts outward rectifying tonic currents potentiated by purinergic signals (PubMed:24163367, PubMed:25148687, PubMed:30472253, PubMed:38409076). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:25148687). Contributes most of K(+) currents at the plasma membrane of resting microglia. Maintains a depolarized membrane potential required for proper ramified microglia morphology and phagocytosis, selectively mediating microglial pruning of presynaptic compartments at hippocampal excitatory synapses (PubMed:38409076). Upon local release of ATP caused by neuronal injury or infection, it is potentiated by P2RY12 and P2RX7 receptor signaling and contributes to ATP-triggered K(+) efflux underlying microglial NLRP3 inflammasome assembly and IL1B release (By similarity) (PubMed:38409076)