Potassium channel subfamily K member 12 (Tandem pore domain halothane-inhibited potassium channel 2) (THIK-2)
1_MSSRS 6_ PRPPP 11_ RRSRR 16_ RLPRP 21_ SCCCC 26_ CCRRS 31_ HLNED 36_ TGRFV 41_ LLAAL 46_ IGLYL 51_ VAGAT 56_ VFSAL 61_ ESPGE 66_ AEARA 71_ RWGAT 76_ LRNFS 81_ AAHGV 86_ AEPEL 91_ RAFLR 96_ HYEAA 101_ LAAGV 106_ RADAL 111_ RPRWD 116_ FPGAF 121_ YFVGT 126_ VVSTI 131_ GFGMT 136_ TPATV 141_ GGKAF 146_ LIAYG 151_ LFGCA 156_ GTILF 161_ FNLFL 166_ ERIIS 171_ LLAFI 176_ MRACR 181_ ERQLR 186_ RSGLL 191_ PATFR 196_ RGSAL 201_ SEADS 206_ LAGWK 211_ PSVYH 216_ VLLIL 221_ GLFAV 226_ LLSCC 231_ ASAMY 236_ TSVEG 241_ WDYVD 246_ SLYFC 251_ FVTFS 256_ TIGFG 261_ DLVSS 266_ QHAAY 271_ RNQGL 276_ YRLGN 281_ FLFIL 286_ LGVCC 291_ IYSLF 296_ NVISI 301_ LIKQV 306_ LNWML 311_ RKLSC 316_ RCCAR 321_ CCPAP 326_ GAPLA 331_ RRNAI 336_ TPGSR 341_ LRRRL 346_ AALGA 351_ DPAAR 356_ DSDAE 361_ GRRLS 366_ GELIS 371_ MRDLT 376_ ASNKV 381_ SLALL 386_ QKQLS 391_ ETANG 396_ YPRSV 401_ CVNTR 406_ QNGFS 411_ GGVGA 416_ LGIMN 421_NRLAE
1: K(+) channel subunit that may homo- and heterodimerize to form functional channels with distinct regulatory and gating properties. Can heterodimerize with KCNK13 subunit to conduct K(+) outward rectifying currents at the plasma membrane. The homodimers are mainly retained in the endoplasmic reticulum compartment and may be targeted to the cell surface upon phosphorylation or other activation signals yet to be elucidated