Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1)
1_MEGVL 6_ YKWTN 11_ YLTGW 16_ QPRWF 21_ VLDNG 26_ ILSYY 31_ DSQDD 36_ VCKGS 41_ KGSIK 46_ MAVCE 51_ IKVHS 56_ ADNTR 61_ MELII 66_ PGEQH 71_ FYMKA 76_ VNAAE 81_ RQRWL 86_ VALGS 91_ SKACL 96_ TDTRT 101_ KKEKE 106_ ISETS 111_ ESLKT 116_ KMSEL 121_ RLYCD 126_ LLMQQ 131_ VHTIQ 136_ EFVHH 141_ DENHS 146_ SPSAE 151_ NMNEA 156_ SSLLS 161_ ATCNT 166_ FITTL 171_ EECVK 176_ IANAK 181_ FKPEM 186_ FQLHH 191_ PDPLV 196_ SPVSP 201_ SPVQM 206_ MKRSV 211_ SHPGS 216_ CSSER 221_ SSHSI 226_ KEPVS 231_ TLHRL 236_ SQRRR 241_ RTYSD 246_ TDSCS 251_ DIPLE 256_ DPDRP 261_ VHCSK 266_ NTLNG 271_ DLASA 276_ TIPEE 281_ SRLMA 286_ KKQSE 291_SEDTL
1: Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (PubMed:30659099). Binds preferentially to PtdIns(4)P (PubMed:11001876, PubMed:15107860). Negatively regulates APOB secretion from hepatocytes (PubMed:30659099)