RNA polymerase II elongation factor ELL3
1_MEELQ 6_ EPLRG 11_ QLRLC 16_ FTQAA 21_ RTSLL 26_ LLRLN 31_ DAALR 36_ ALQEC 41_ QRQQV 46_ RPVIA 51_ FQGHR 56_ GYLRL 61_ PGPGW 66_ SCLFS 71_ FIVSQ 76_ CCQEG 81_ AGGSL 86_ DLVCQ 91_ RFLRS 96_ GPNSL 101_ HCLGS 106_ LRERL 111_ IIWAA 116_ MDSIP 121_ APSSV 126_ QGHNL 131_ TEDAR 136_ HPESW 141_ QNTGG 146_ YSEGD 151_ AVSQP 156_ QMALE 161_ EVSVS 166_ DPLAS 171_ NQGQS 176_ LPGSS 181_ REHMA 186_ QWEVR 191_ SQTHV 196_ PNREP 201_ VQALP 206_ SSASR 211_ KRLDK 216_ KRSVP 221_ VATVE 226_ LEEKR 231_ FRTLP 236_ LVPSP 241_ LQGLT 246_ NQDLQ 251_ EGEDW 256_ EQEDE 261_ DMDPR 266_ LEHSS 271_ SVQED 276_ SESPS 281_ PEDIP 286_ DYLLQ 291_ YRAIH 296_ SAEQQ 301_ HAYEQ 306_ DFETD 311_ YAEYR 316_ ILHAR 321_ VGTAS 326_ QRFIE 331_ LGAEI 336_ KRVRR 341_ GTPEY 346_ KVLED 351_ KIIQE 356_ YKKFR 361_ KQYPS 366_ YREEK 371_ RRCEY 376_ LHQKL 381_ SHIKG 386_ LILEF 391_EEKNR
1: Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968)