p53-induced death domain-containing protein 1 (EC 3.4.21.-) (Leucine-rich repeat and death domain-containing protein) [Cleaved into: PIDD-N; PIDD-C; PIDD-CC]
1_MAATV 6_ EGPEL 11_ EAAAA 16_ AGDAS 21_ EDSDA 26_ GSRAL 31_ PFLGG 36_ NRLSL 41_ DLYPG 46_ GCQQL 51_ LHLCV 56_ QQPLQ 61_ LLQVE 66_ FLRLS 71_ THEDP 76_ QLLEA 81_ TLAQL 86_ PQSLS 91_ CLRSL 96_ VLKGG 101_ QRRDT 106_ LGACL 111_ RGALT 116_ NLPAG 121_ LSGLA 126_ HLAHL 131_ DLSFN 136_ SLETL 141_ PACVL 146_ QMRGL 151_ GALLL 156_ SHNCL 161_ SELPE 166_ ALGAL 171_ PALTF 176_ LTVTH 181_ NRLQT 186_ LPPAL 191_ GALST 196_ LQRLD 201_ LSQNL 206_ LDTLP 211_ PEIGG 216_ LGSLL 221_ ELNLA 226_ SNRLQ 231_ SLPAS 236_ LAGLR 241_ SLRLL 246_ VLHSN 251_ LLASV 256_ PADLA 261_ RLPLL 266_ TRLDL 271_ RDNQL 276_ RDLPP 281_ ELLDA 286_ PFVRL 291_ QGNPL 296_ GEASP 301_ DAPSS 306_ PVAAL 311_ IPEMP 316_ RLFLT 321_ SDLDS 326_ FPVTP 331_ QGCSV 336_ TLACG 341_ VRLQF 346_ PAGAT 351_ ATPIT 356_ IRYRL 361_ LLPEP 366_ GLVPL 371_ GPHDA 376_ LLSHV 381_ LELQP 386_ HGVAF 391_ QQDVG 396_ LWLLF 401_ TPPQA 406_ RRCRE 411_ VVVRT 416_ RNDNS 421_ WGDLE 426_ TYLEE 431_ EAPQR 436_ LWAHC 441_ QVPHF 446_ SWFLV 451_ VSRPV 456_ SNACL 461_ VPPEG 466_ TLLCS 471_ SGHPG 476_ VKVIF 481_ PPGAT 486_ EEPRR 491_ VSMQV 496_ VRMAG 501_ RELQA 506_ LLGEP 511_ EAAVS 516_ PLLCL 521_ SQSGP 526_ PSFLQ 531_ PVTVQ 536_ LPLPS 541_ GITGL 546_ SLDRS 551_ RLHLL 556_ YWAPP 561_ AATWD 566_ DITAQ 571_ VVLEL 576_ THLYA 581_ RFQVT 586_ HFSWY 591_ WLWYT 596_ TKNCV 601_ GGLAR 606_ KAWER 611_ LRLHR 616_ VNLIA 621_ LQRRR 626_ DPEQV 631_ LLQCL 636_ PRNKV 641_ DATLR 646_ RLLER 651_ YRGPE 656_ PSDTV 661_ EMFEG 666_ EEFFA 671_ AFERG 676_ IDVDA 681_ DRPDC 686_ VEGRI 691_ CFVFY 696_ SHLKN 701_ VKEVY 706_ VTTTL 711_ DREAQ 716_ AVRGQ 721_ VSFYR 726_ GAVPV 731_ RVPEE 736_ AEAAR 741_ QRKGA 746_ DALWM 751_ ATLPI 756_ KLPRL 761_ RGSEG 766_ PRRGA 771_ GLSLA 776_ PLNLG 781_ DAETG 786_ FLTQS 791_ NLLSV 796_ AGRLG 801_ LDWPA 806_ VALHL 811_ GVSYR 816_ EVQRI 821_ RHEFR 826_ DDLDE 831_ QIRHM 836_ LFSWA 841_ ERQAG 846_ QPGAV 851_ GLLVQ 856_ ALEQS 861_ DRQDV 866_ AEEVR 871_ AVLEL 876_ GRRKY 881_ QDSIR 886_ RMGLA 891_ PKDPA 896_ LPGSS 901_APQPP
1: Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis (PubMed:10973264, PubMed:15073321, PubMed:16360037, PubMed:17159900). Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis (PubMed:15073321, PubMed:17159900). Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (PubMed:16360037, PubMed:17159900)