Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC)
1_MADSS 6_ EGPRA 11_ GPGEV 16_ AELPG 21_ DESGT 26_ PGGEA 31_ FPLSS 36_ LANLF 41_ EGEDG 46_ SLSPS 51_ PADAS 56_ RPAGP 61_ GDGRP 66_ NLRMK 71_ FQGAF 76_ RKGVP 81_ NPIDL 86_ LESTL 91_ YESSV 96_ VPGPK 101_ KAPMD 106_ SLFDY 111_ GTYRH 116_ HSSDN 121_ KRWRK 126_ KIIEK 131_ QPQSP 136_ KAPAP 141_ QPPPI 146_ LKVFN 151_ RPILF 156_ DIVSR 161_ GSTAD 166_ LDGLL 171_ PFLLT 176_ HKKRL 181_ TDEEF 186_ REPST 191_ GKTCL 196_ PKALL 201_ NLSNG 206_ RNDTI 211_ PVLLD 216_ IAERT 221_ GNMRE 226_ FINSP 231_ FRDIY 236_ YRGQT 241_ ALHIA 246_ IERRC 251_ KHYVE 256_ LLVAQ 261_ GADVH 266_ AQARG 271_ RFFQP 276_ KDEGG 281_ YFYFG 286_ ELPLS 291_ LAACT 296_ NQPHI 301_ VNYLT 306_ ENPHK 311_ KADMR 316_ RQDSR 321_ GNTVL 326_ HALVA 331_ IADNT 336_ RENTK 341_ FVTKM 346_ YDLLL 351_ LKCAR 356_ LFPDS 361_ NLEAV 366_ LNNDG 371_ LSPLM 376_ MAAKT 381_ GKIGI 386_ FQHII 391_ RREVT 396_ DEDTR 401_ HLSRK 406_ FKDWA 411_ YGPVY 416_ SSLYD 421_ LSSLD 426_ TCGEE 431_ ASVLE 436_ ILVYN 441_ SKIEN 446_ RHEML 451_ AVEPI 456_ NELLR 461_ DKWRK 466_ FGAVS 471_ FYINV 476_ VSYLC 481_ AMVIF 486_ TLTAY 491_ YQPLE 496_ GTPPY 501_ PYRTT 506_ VDYLR 511_ LAGEV 516_ ITLFT 521_ GVLFF 526_ FTNIK 531_ DLFMK 536_ KCPGV 541_ NSLFI 546_ DGSFQ 551_ LLYFI 556_ YSVLV 561_ IVSAA 566_ LYLAG 571_ IEAYL 576_ AVMVF 581_ ALVLG 586_ WMNAL 591_ YFTRG 596_ LKLTG 601_ TYSIM 606_ IQKIL 611_ FKDLF 616_ RFLLV 621_ YLLFM 626_ IGYAS 631_ ALVSL 636_ LNPCA 641_ NMKVC 646_ NEDQT 651_ NCTVP 656_ TYPSC 661_ RDSET 666_ FSTFL 671_ LDLFK 676_ LTIGM 681_ GDLEM 686_ LSSTK 691_ YPVVF 696_ IILLV 701_ TYIIL 706_ TFVLL 711_ LNMLI 716_ ALMGE 721_ TVGQV 726_ SKESK 731_ HIWKL 736_ QWATT 741_ ILDIE 746_ RSFPV 751_ FLRKA 756_ FRSGE 761_ MVTVG 766_ KSSDG 771_ TPDRR 776_ WCFRV 781_ DEVNW 786_ SHWNQ 791_ NLGII 796_ NEDPG 801_ KNETY 806_ QYYGF 811_ SHTVG 816_ RLRRD 821_ RWSSV 826_ VPRVV 831_ ELNKN 836_ SNPDE 841_ VVVPL 846_ DSMGN 851_ PRCDG 856_ HQQGY 861_ PRKWR 866_TDDAP
1: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:16293632, PubMed:18695040, PubMed:18826956, PubMed:22526352, PubMed:23136043, PubMed:29899501). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18695040, PubMed:18826956, PubMed:29899501). Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18695040, PubMed:18826956, PubMed:20037586, PubMed:21964574, PubMed:25256292). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to pro-inflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (PubMed:26249260). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (PubMed:29899501). In neurons of the central nervous system, could play a role in triggering voluntary water intake in response to increased sodium concentration in body fluid (By similarity)
2: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli
3: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli
4: Lacks channel activity, due to impaired oligomerization and intracellular retention
5: Lacks channel activity, due to impaired oligomerization and intracellular retention
6: Lacks channel activity, due to impaired oligomerization and intracellular retention
7: (Microbial infection) Facilitates hepatitis C virus (HCV) replication, possibly through its action on DDX3X
8: (Microbial infection) Facilitates Dengue virus (DENV) replication, possibly through its action on DDX3X
9: (Microbial infection) Facilitates Zika virus (ZIKV) replication, possibly through its action on DDX3X