Interleukin-21 (IL-21) (Za11)
1_MRSSP 6_ GNMER 11_ IVICL 16_ MVIFL 21_ GTLVH 26_ KSSSQ 31_ GQDRH 36_ MIRMR 41_ QLIDI 46_ VDQLK 51_ NYVND 56_ LVPEF 61_ LPAPE 66_ DVETN 71_ CEWSA 76_ FSCFQ 81_ KAQLK 86_ SANTG 91_ NNERI 96_ INVSI 101_ KKLKR 106_ KPPST 111_ NAGRR 116_ QKHRL 121_ TCPSC 126_ DSYEK 131_ KPPKE 136_ FLERF 141_ KSLLQ 146_ KMIHQ 151_ HLSSR 156_THGSE
1: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (PubMed:11081504, PubMed:15178704). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity)