Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (SR3) (Tandem FYVE fingers-1)
1_MSAQT 6_ SPAEK 11_ GLNPG 16_ LMCQE 21_ SYACS 26_ GTDEA 31_ IFECD 36_ ECCSL 41_ QCLRC 46_ EEELH 51_ RQERL 56_ RNHER 61_ IRLKP 66_ GHVPY 71_ CDLCK 76_ GLSGH 81_ LPGVR 86_ QRAIV 91_ RCQTC 96_ KINLC 101_ LECQK 106_ RTHSG 111_ GNKRR 116_ HPVTV 121_ YNVSN 126_ LQESL 131_ EAEEM 136_ DEETK 141_ RKKMT 146_ EKVVS 151_ FLLVD 156_ ENEEI 161_ QVTNE 166_ EDFIR 171_ KLDCK 176_ PDQHL 181_ KVVSI 186_ FGNTG 191_ DGKSH 196_ TLNHT 201_ FFYGR 206_ EVFKT 211_ SPTQE 216_ SCTVG 221_ VWAAY 226_ DPVHK 231_ VAVID 236_ TEGLL 241_ GATVN 246_ LSQRT 251_ RLLLK 256_ VLAIS 261_ DLVIY 266_ RTHAD 271_ RLHND 276_ LFKFL 281_ GDASE 286_ AYLKH 291_ FTKEL 296_ KATTA 301_ RCGLD 306_ VPLST 311_ LGPAV 316_ IIFHE 321_ TVHTQ 326_ LLGSD 331_ HPSEV 336_ PEKLI 341_ QDRFR 346_ KLGRF 351_ PEAFS 356_ SIHYK 361_ GTRTY 366_ NPPTD 371_ FSGLR 376_ RALEQ 381_ LLENN 386_ TTRSP 391_ RHPGV 396_ IFKAL 401_ KALSD 406_ RFSGE 411_ IPDDQ 416_ MAHSS 421_ FFPDE 426_ YFTCS 431_ SLCLS 436_ CGVGC 441_ KKSMN 446_ HGKEG 451_ VPHEA 456_ KSRCR 461_ YSHQY 466_ DNRVY 471_ TCKAC 476_ YERGE 481_ EVSVV 486_ PKTSA 491_ STDSP 496_ WMGLA 501_ KYAWS 506_ GYVIE 511_ CPNCG 516_ VVYRS 521_ RQYWF 526_ GNQDP 531_ VDTVV 536_ RTEIV 541_ HVWPG 546_ TDGFL 551_ KDNNN 556_ AAQRL 561_ LDGMN 566_ FMAQS 571_ VSELS 576_ LGPTK 581_ AVTSW 586_ LTDQI 591_ APAYW 596_ RPNSQ 601_ ILSCN 606_ KCATS 611_ FKDND 616_ TKHHC 621_ RACGE 626_ GFCDS 631_ CSSKT 636_ RPVPE 641_ RGWGP 646_ APVRV 651_ CDNCY 656_ EARNV 661_ QLAVT 666_ EAQVD 671_ DEGGT 676_ LIARK 681_ VGEAV 686_ QNTLG 691_ AVVTA 696_ IDIPL 701_ GLVKD 706_ AARPA 711_ YWVPD 716_ HEILH 721_ CHNCR 726_ KEFSI 731_ KLSKH 736_ HCRAC 741_ GQGFC 746_ DECSH 751_ DRRAV 756_ PSRGW 761_ DHPVR 766_ VCFNC 771_NKKPG
1: Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241). Regulates the morphology, size and distribution of LDs (PubMed:30970241, PubMed:31293035). Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10 (PubMed:30970241). Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (PubMed:11256955, PubMed:11739631)
2: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, mediates through binding with non-structural protein 6 (nsp6) the replication organelle-lipid droplet association required to sustain viral replication