Protein BEX1 (Brain-expressed X-linked protein 1)
1_MESKE 6_ KRAVN 11_ SLSME 16_ NANQE 21_ NEEKE 26_ QVANK 31_ GEPLA 36_ LPLDA 41_ GEYCV 46_ PRGNR 51_ RRFRV 56_ RQPIL 61_ QYRWD 66_ MMHRL 71_ GEPQA 76_ RMREE 81_ NMERI 86_ GEEVR 91_ QLMEK 96_ LREKQ 101_ LSHSL 106_ RAVST 111_ DPPHH 116_DHHDE
1: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity)