MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2)
1_MVQKK 6_ PAELQ 11_ GFHRS 16_ FKGQN 21_ PFELA 26_ FSLDQ 31_ PDHGD 36_ SDFGL 41_ QCSAR 46_ PDMPA 51_ SQPID 56_ IPDAK 61_ KRGKK 66_ KKRGR 71_ ATDSF 76_ SGRFE 81_ DVYQL 86_ QEDVL 91_ GEGAH 96_ ARVQT 101_ CINLI 106_ TSQEY 111_ AVKII 116_ EKQPG 121_ HIRSR 126_ VFREV 131_ EMLYQ 136_ CQGHR 141_ NVLEL 146_ IEFFE 151_ EEDRF 156_ YLVFE 161_ KMRGG 166_ SILSH 171_ IHKRR 176_ HFNEL 181_ EASVV 186_ VQDVA 191_ SALDF 196_ LHNKG 201_ IAHRD 206_ LKPEN 211_ ILCEH 216_ PNQVS 221_ PVKIC 226_ DFDLG 231_ SGIKL 236_ NGDCS 241_ PISTP 246_ ELLTP 251_ CGSAE 256_ YMAPE 261_ VVEAF 266_ SEEAS 271_ IYDKR 276_ CDLWS 281_ LGVIL 286_ YILLS 291_ GYPPF 296_ VGRCG 301_ SDCGW 306_ DRGEA 311_ CPACQ 316_ NMLFE 321_ SIQEG 326_ KYEFP 331_ DKDWA 336_ HISCA 341_ AKDLI 346_ SKLLV 351_ RDAKQ 356_ RLSAA 361_ QVLQH 366_ PWVQG 371_ CAPEN 376_ TLPTP 381_ MVLQR 386_ NSCAK 391_ DLTSF 396_ AAEAI 401_ AMNRQ 406_ LAQHD 411_ EDLAE 416_ EEAAG 421_ QGQPV 426_ LVRAT 431_ SRCLQ 436_ LSPPS 441_ QSKLA 446_ QRRQR 451_ ASLSS 456_APVVL
1: Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal