Gene name: PARVB

Uniprot entry:

Q9HBI1

Protein names:

Beta-parvin (Affixin)

Protein sequence:

1_MSSAP 6_ RSPTP 11_ RPRRM 16_ KKDES 21_ FLGKL 26_ GGTLA 31_ RKRRA 36_ REVSD 41_ LQEEG 46_ KNAIN 51_ SPMSP 56_ ALVDV 61_ HPEDT 66_ QLEEN 71_ EERTM 76_ IDPTS 81_ KEDPK 86_ FKELV 91_ KVLLD 96_ WINDV 101_ LVEER 106_ IIVKQ 111_ LEEDL 116_ YDGQV 121_ LQKLL 126_ EKLAG 131_ CKLNV 136_ AEVTQ 141_ SEIGQ 146_ KQKLQ 151_ TVLEA 156_ VHDLL 161_ RPRGW 166_ ALRWS 171_ VDSIH 176_ GKNLV 181_ AILHL 186_ LVSLA 191_ MHFRA 196_ PIRLP 201_ EHVTV 206_ QVVVV 211_ RKREG 216_ LLHSS 221_ HISEE 226_ LTTTT 231_ EMMMG 236_ RFERD 241_ AFDTL 246_ FDHAP 251_ DKLSV 256_ VKKSL 261_ ITFVN 266_ KHLNK 271_ LNLEV 276_ TELET 281_ QFADG 286_ VYLVL 291_ LMGLL 296_ EDYFV 301_ PLHHF 306_ YLTPE 311_ SFDQK 316_ VHNVS 321_ FAFEL 326_ MLDGG 331_ LKKPK 336_ ARPED 341_ VVNLD 346_ LKSTL 351_ RVLYN 356_LFTKY

Protein annotations

Protein functions:

1: Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration