Cytochrome P450 4F11 (CYPIVF11) (EC 1.14.14.1) (3-hydroxy fatty acids omega-hydroxylase CYP4F11) (Docosahexaenoic acid omega-hydroxylase) (EC 1.14.14.79) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80) (Phylloquinone omega-hydroxylase CYP4F11) (EC 1.14.14.78)
1_MPQLS 6_ LSWLG 11_ LGPVA 16_ ASPWL 21_ LLLLV 26_ GGSWL 31_ LARVL 36_ AWTYT 41_ FYDNC 46_ RRLQC 51_ FPQPP 56_ KQNWF 61_ WGHQG 66_ LVTPT 71_ EEGMK 76_ TLTQL 81_ VTTYP 86_ QGFKL 91_ WLGPT 96_ FPLLI 101_ LCHPD 106_ IIRPI 111_ TSASA 116_ AVAPK 121_ DMIFY 126_ GFLKP 131_ WLGDG 136_ LLLSG 141_ GDKWS 146_ RHRRM 151_ LTPAF 156_ HFNIL 161_ KPYMK 166_ IFNKS 171_ VNIMH 176_ DKWQR 181_ LASEG 186_ SARLD 191_ MFEHI 196_ SLMTL 201_ DSLQK 206_ CVFSF 211_ ESNCQ 216_ EKPSE 221_ YIAAI 226_ LELSA 231_ FVEKR 236_ NQQIL 241_ LHTDF 246_ LYYLT 251_ PDGQR 256_ FRRAC 261_ HLVHD 266_ FTDAV 271_ IQERR 276_ CTLPT 281_ QGIDD 286_ FLKNK 291_ AKSKT 296_ LDFID 301_ VLLLS 306_ KDEDG 311_ KELSD 316_ EDIRA 321_ EADTF 326_ MFEGH 331_ DTTAS 336_ GLSWV 341_ LYHLA 346_ KHPEY 351_ QEQCR 356_ QEVQE 361_ LLKDR 366_ EPIEI 371_ EWDDL 376_ AQLPF 381_ LTMCI 386_ KESLR 391_ LHPPV 396_ PVISR 401_ CCTQD 406_ FVLPD 411_ GRVIP 416_ KGIVC 421_ LINII 426_ GIHYN 431_ PTVWP 436_ DPEVY 441_ DPFRF 446_ DQENI 451_ KERSP 456_ LAFIP 461_ FSAGP 466_ RNCIG 471_ QAFAM 476_ AEMKV 481_ VLALT 486_ LLHFR 491_ ILPTH 496_ TEPRR 501_ KPELI 506_ LRAEG 511_ GLWLR 516_VEPLG
1: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins) (PubMed:15364545, PubMed:18065749, PubMed:24138531, PubMed:37373382). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:15364545, PubMed:18065749, PubMed:24138531, PubMed:37373382). Catalyzes with high efficiency the oxidation of the terminal carbon (omega-oxidation) of 3-hydroxy fatty acids, such as 3-hydroxyhexadecanoic and 3-hydroxyoctadecanoic acids, likely participating in the biosynthesis of long-chain 3-hydroxydicarboxylic acids (PubMed:18065749, PubMed:19932081). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:24138531). Metabolizes with low efficiciency fatty acids, including (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) and its oxygenated metabolite 8-hydroxyeicosatetraenoic acid (8-HETE) (PubMed:15364545, PubMed:19932081). Catalyzes N- and O-demethylation of drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine, imipramine and verapamil (PubMed:15364545). Catalyzes the oxidation of dialkylresorcinol 2 (PubMed:36565673)