Arsenite methyltransferase (EC 2.1.1.137) (Methylarsonite methyltransferase) (S-adenosyl-L-methionine:arsenic(III) methyltransferase)
1_MAALR 6_ DAEIQ 11_ KDVQT 16_ YYGQV 21_ LKRSA 26_ DLQTN 31_ GCVTT 36_ ARPVP 41_ KHIRE 46_ ALQNV 51_ HEEVA 56_ LRYYG 61_ CGLVI 66_ PEHLE 71_ NCWIL 76_ DLGSG 81_ SGRDC 86_ YVLSQ 91_ LVGEK 96_ GHVTG 101_ IDMTK 106_ GQVEV 111_ AEKYL 116_ DYHME 121_ KYGFQ 126_ ASNVT 131_ FIHGY 136_ IEKLG 141_ EAGIK 146_ NESHD 151_ IVVSN 156_ CVINL 161_ VPDKQ 166_ QVLQE 171_ AYRVL 176_ KHGGE 181_ LYFSD 186_ VYTSL 191_ ELPEE 196_ IRTHK 201_ VLWGE 206_ CLGGA 211_ LYWKE 216_ LAVLA 221_ QKIGF 226_ CPPRL 231_ VTANL 236_ ITIQN 241_ KELER 246_ VIGDC 251_ RFVSA 256_ TFRLF 261_ KHSKT 266_ GPTKR 271_ CQVIY 276_ NGGIT 281_ GHEKE 286_ LMFDA 291_ NFTFK 296_ EGEIV 301_ EVDEE 306_ TAAIL 311_ KNSRF 316_ AQDFL 321_ IRPIG 326_ EKLPT 331_ SGGCS 336_ ALELK 341_ DIITD 346_ PFKLA 351_ EESDS 356_ MKSRC 361_ VPDAA 366_GGCCG
1: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals (PubMed:16407288, PubMed:25997655). It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2 (PubMed:16407288, PubMed:25997655). Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (PubMed:16407288, PubMed:25997655)