Gene name: SPC25

Uniprot entry:

Q9HBM1

Protein names:

Kinetochore protein Spc25 (hSpc25)

Protein sequence:

1_MVEDE 6_ LALFD 11_ KSINE 16_ FWNKF 21_ KSTDT 26_ SCQMA 31_ GLRDT 36_ YKDSI 41_ KAFAE 46_ KLSVK 51_ LKEEE 56_ RMVEM 61_ FLEYQ 66_ NQISR 71_ QNKLI 76_ QEKKD 81_ NLLKL 86_ IAEVK 91_ GKKQE 96_ LEVLT 101_ ANIQD 106_ LKEEY 111_ SRKKE 116_ TISTA 121_ NKANA 126_ ERLKR 131_ LQKSA 136_ DLYKD 141_ RLGLE 146_ IRKIY 151_ GEKLQ 156_ FIFTN 161_ IDPKN 166_ PESPF 171_ MFSLH 176_ LNEAR 181_ DYEVS 186_ DSAPH 191_ LEGLA 196_ EFQEN 201_ VRKTN 206_ NFSAF 211_ LANVR 216_KAFTA

Protein annotations

Protein functions:

1: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14699129, PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020)