Leucine-rich repeat-containing G-protein coupled receptor 6
1_MPSPP 6_ GLRAL 11_ WLCAA 16_ LCASR 21_ RAGGA 26_ PQPGP 31_ GPTAC 36_ PAPCH 41_ CQEDG 46_ IMLSA 51_ DCSEL 56_ GLSAV 61_ PGDLD 66_ PLTAY 71_ LDLSM 76_ NNLTE 81_ LQPGL 86_ FHHLR 91_ FLEEL 96_ RLSGN 101_ HLSHI 106_ PGQAF 111_ SGLYS 116_ LKILM 121_ LQNNQ 126_ LGGIP 131_ AEALW 136_ ELPSL 141_ QSLRL 146_ DANLI 151_ SLVPE 156_ RSFEG 161_ LSSLR 166_ HLWLD 171_ DNALT 176_ EIPVR 181_ ALNNL 186_ PALQA 191_ MTLAL 196_ NRISH 201_ IPDYA 206_ FQNLT 211_ SLVVL 216_ HLHNN 221_ RIQHL 226_ GTHSF 231_ EGLHN 236_ LETLD 241_ LNYNK 246_ LQEFP 251_ VAIRT 256_ LGRLQ 261_ ELGFH 266_ NNNIK 271_ AIPEK 276_ AFMGN 281_ PLLQT 286_ IHFYD 291_ NPIQF 296_ VGRSA 301_ FQYLP 306_ KLHTL 311_ SLNGA 316_ MDIQE 321_ FPDLK 326_ GTTSL 331_ EILTL 336_ TRAGI 341_ RLLPS 346_ GMCQQ 351_ LPRLR 356_ VLELS 361_ HNQIE 366_ ELPSL 371_ HRCQK 376_ LEEIG 381_ LQHNR 386_ IWEIG 391_ ADTFS 396_ QLSSL 401_ QALDL 406_ SWNAI 411_ RSIHP 416_ EAFST 421_ LHSLV 426_ KLDLT 431_ DNQLT 436_ TLPLA 441_ GLGGL 446_ MHLKL 451_ KGNLA 456_ LSQAF 461_ SKDSF 466_ PKLRI 471_ LEVPY 476_ AYQCC 481_ PYGMC 486_ ASFFK 491_ ASGQW 496_ EAEDL 501_ HLDDE 506_ ESSKR 511_ PLGLL 516_ ARQAE 521_ NHYDQ 526_ DLDEL 531_ QLEME 536_ DSKPH 541_ PSVQC 546_ SPTPG 551_ PFKPC 556_ EYLFE 561_ SWGIR 566_ LAVWA 571_ IVLLS 576_ VLCNG 581_ LVLLT 586_ VFAGG 591_ PVPLP 596_ PVKFV 601_ VGAIA 606_ GANTL 611_ TGISC 616_ GLLAS 621_ VDALT 626_ FGQFS 631_ EYGAR 636_ WETGL 641_ GCRAT 646_ GFLAV 651_ LGSEA 656_ SVLLL 661_ TLAAV 666_ QCSVS 671_ VSCVR 676_ AYGKS 681_ PSLGS 686_ VRAGV 691_ LGCLA 696_ LAGLA 701_ AALPL 706_ ASVGE 711_ YGASP 716_ LCLPY 721_ APPEG 726_ QPAAL 731_ GFTVA 736_ LVMMN 741_ SFCFL 746_ VVAGA 751_ YIKLY 756_ CDLPR 761_ GDFEA 766_ VWDCA 771_ MVRHV 776_ AWLIF 781_ ADGLL 786_ YCPVA 791_ FLSFA 796_ SMLGL 801_ FPVTP 806_ EAVKS 811_ VLLVV 816_ LPLPA 821_ CLNPL 826_ LYLLF 831_ NPHFR 836_ DDLRR 841_ LRPRA 846_ GDSGP 851_ LAYAA 856_ AGELE 861_ KSSCD 866_ STQAL 871_ VAFSD 876_ VDLIL 881_ EASEA 886_ GRPPG 891_ LETYG 896_ FPSVT 901_ LISCQ 906_ QPGAP 911_ RLEGS 916_ HCVEP 921_ EGNHF 926_ GNPQP 931_ SMDGE 936_ LLLRA 941_ EGSTP 946_ AGGGL 951_ SGGGG 956_ FQPSG 961_LAFAS
1: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor