Transmembrane protein 165 (Transmembrane protein PT27) (Transmembrane protein TPARL)
1_MAAAA 6_ PGNGR 11_ ASAPR 16_ LLLLF 21_ LVPLL 26_ WAPAA 31_ VRAGP 36_ DEDLS 41_ HRNKE 46_ PPAPA 51_ QQLQP 56_ QPVAV 61_ QGPEP 66_ ARVEK 71_ IFTPA 76_ APVHT 81_ NKEDP 86_ ATQTN 91_ LGFIH 96_ AFVAA 101_ ISVII 106_ VSELG 111_ DKTFF 116_ IAAIM 121_ AMRYN 126_ RLTVL 131_ AGAML 136_ ALGLM 141_ TCLSV 146_ LFGYA 151_ TTVIP 156_ RVYTY 161_ YVSTV 166_ LFAIF 171_ GIRML 176_ REGLK 181_ MSPDE 186_ GQEEL 191_ EEVQA 196_ ELKKK 201_ DEEFQ 206_ RTKLL 211_ NGPGD 216_ VETGT 221_ SITVP 226_ QKKWL 231_ HFISP 236_ IFVQA 241_ LTLTF 246_ LAEWG 251_ DRSQL 256_ TTIVL 261_ AARED 266_ PYGVA 271_ VGGTV 276_ GHCLC 281_ TGLAV 286_ IGGRM 291_ IAQKI 296_ SVRTV 301_ TIIGG 306_ IVFLA 311_ FAFSA 316_LFISP
1: Putative divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway (By similarity) (PubMed:22683087, PubMed:23569283, PubMed:27008884, PubMed:32047108). Promotes Ca(2+) storage within the Golgi lumen of the mammary epithelial cells to be then secreted into milk (By similarity). The transport mechanism and stoichiometry remains to be elucidated