DNA dC->dU-editing enzyme APOBEC-3G (EC 3.5.4.38) (APOBEC-related cytidine deaminase) (APOBEC-related protein) (ARCD) (APOBEC-related protein 9) (ARP-9) (CEM-15) (CEM15) (Deoxycytidine deaminase) (A3G)
1_MKPHF 6_ RNTVE 11_ RMYRD 16_ TFSYN 21_ FYNRP 26_ ILSRR 31_ NTVWL 36_ CYEVK 41_ TKGPS 46_ RPPLD 51_ AKIFR 56_ GQVYS 61_ ELKYH 66_ PEMRF 71_ FHWFS 76_ KWRKL 81_ HRDQE 86_ YEVTW 91_ YISWS 96_ PCTKC 101_ TRDMA 106_ TFLAE 111_ DPKVT 116_ LTIFV 121_ ARLYY 126_ FWDPD 131_ YQEAL 136_ RSLCQ 141_ KRDGP 146_ RATMK 151_ IMNYD 156_ EFQHC 161_ WSKFV 166_ YSQRE 171_ LFEPW 176_ NNLPK 181_ YYILL 186_ HIMLG 191_ EILRH 196_ SMDPP 201_ TFTFN 206_ FNNEP 211_ WVRGR 216_ HETYL 221_ CYEVE 226_ RMHND 231_ TWVLL 236_ NQRRG 241_ FLCNQ 246_ APHKH 251_ GFLEG 256_ RHAEL 261_ CFLDV 266_ IPFWK 271_ LDLDQ 276_ DYRVT 281_ CFTSW 286_ SPCFS 291_ CAQEM 296_ AKFIS 301_ KNKHV 306_ SLCIF 311_ TARIY 316_ DDQGR 321_ CQEGL 326_ RTLAE 331_ AGAKI 336_ SIMTY 341_ SEFKH 346_ CWDTF 351_ VDHQG 356_ CPFQP 361_ WDGLD 366_ EHSQD 371_ LSGRL 376_RAILQ
1: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms (PubMed:12808465, PubMed:16527742, PubMed:17121840, PubMed:18288108, PubMed:18849968, PubMed:19153609, PubMed:21123384, PubMed:22791714, PubMed:25542899). Exhibits potent antiviral activity against Vif-deficient HIV-1 (PubMed:12167863, PubMed:12859895, PubMed:14557625, PubMed:20219927, PubMed:21835787, PubMed:22807680, PubMed:22915799, PubMed:23097438, PubMed:23152537, PubMed:31397674). After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA (PubMed:12808465, PubMed:12808466, PubMed:12809610, PubMed:12970355, PubMed:14528300, PubMed:22807680). The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells (PubMed:12808465, PubMed:12808466, PubMed:12809610, PubMed:12970355, PubMed:14528300). Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA (PubMed:12808465, PubMed:12809610, PubMed:12970355, PubMed:14528300). Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) (PubMed:15031497, PubMed:16378963, PubMed:18448976, PubMed:19458006, PubMed:20335265). May inhibit the mobility of LTR and non-LTR retrotransposons (PubMed:16527742)